PMID- 21232544
OWN - NLM
STAT- MEDLINE
DCOM- 20110809
LR  - 20110524
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 711
IP  - 1-2
DP  - 2011 Jun 3
TI  - mBAND analysis for high- and low-LET radiation-induced chromosome aberrations: a 
      review.
PG  - 187-92
LID - 10.1016/j.mrfmmm.2010.12.018 [doi]
AB  - During long-term space travel or cancer therapy, humans are exposed to high 
      linear energy transfer (LET) energetic heavy ions. High-LET radiation is much 
      more effective than low-LET radiation in causing various biological effects, 
      including cell inactivation, genetic mutations, cataracts and cancer induction. 
      Most of these biological endpoints are closely related to chromosomal damage, and 
      cytogenetic damage can be utilized as a biomarker for radiation insults. 
      Epidemiological data, mainly from survivors of the atomic bomb detonations in 
      Japan, have enabled risk estimation from low-LET radiation exposures. The 
      identification of a cytogenetic signature that distinguishes high- from low-LET 
      exposure remains a long-term goal in radiobiology. Recently developed 
      fluorescence in situ hybridization (FISH)-painting methodologies have revealed 
      unique endpoints related to radiation quality. Heavy-ions induce a high fraction 
      of complex-type exchanges, and possibly unique chromosome rearrangements. This 
      review will concentrate on recent data obtained with multicolor banding in situ 
      hybridization (mBAND) methods in mammalian cells exposed to low- and high-LET 
      radiations. Chromosome analysis with mBAND technique allows detection of both 
      inter- and intrachromosomal exchanges, and also distribution of the breakpoints 
      of aberrations.
CI  - 2011 Elsevier B.V. All rights reserved.
FAU - Hada, Megumi
AU  - Hada M
AD  - NASA Johnson Space Center, Houston, TX 77058, USA; Universities Space Research 
      Association, Houston, TX 77058, USA. megumi.hada-1@nasa.gov
FAU - Wu, Honglu
AU  - Wu H
FAU - Cucinotta, Francis A
AU  - Cucinotta FA
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20110111
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
SB  - IM
MH  - Chromosome Aberrations/*radiation effects
MH  - DNA Breaks
MH  - Heavy Ions
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - *Linear Energy Transfer
MH  - Neoplasms/genetics
EDAT- 2011/01/15 06:00
MHDA- 2011/08/10 06:00
CRDT- 2011/01/15 06:00
PHST- 2010/09/17 00:00 [received]
PHST- 2010/12/17 00:00 [revised]
PHST- 2010/12/17 00:00 [accepted]
PHST- 2011/01/15 06:00 [entrez]
PHST- 2011/01/15 06:00 [pubmed]
PHST- 2011/08/10 06:00 [medline]
AID - S0027-5107(11)00005-4 [pii]
AID - 10.1016/j.mrfmmm.2010.12.018 [doi]
PST - ppublish
SO  - Mutat Res. 2011 Jun 3;711(1-2):187-92. doi: 10.1016/j.mrfmmm.2010.12.018. Epub 
      2011 Jan 11.