PMID- 21233853
OWN - NLM
STAT- MEDLINE
DCOM- 20110413
LR  - 20211203
IS  - 1474-1741 (Electronic)
IS  - 1474-1733 (Print)
IS  - 1474-1733 (Linking)
VI  - 11
IP  - 2
DP  - 2011 Feb
TI  - Metabolism, migration and memory in cytotoxic T cells.
PG  - 109-17
LID - 10.1038/nri2888 [doi]
AB  - The transcriptional and metabolic programmes that control CD8(+) T cells are 
      regulated by a diverse network of serine/threonine kinases. The view has been 
      that the kinases AKT and mammalian target of rapamycin (mTOR) control T cell 
      metabolism. Here, we challenge this paradigm and discuss an alternative role for 
      these kinases in CD8(+) T cells, namely to control cell migration. Another 
      emerging concept is that AMP-activated protein kinase (AMPK) family members 
      control T cell metabolism and determine the effector versus memory fate of CD8(+) 
      T cells. We speculate that one link between metabolism and immunological memory 
      is provided by kinases that originally evolved to control T cell metabolism and 
      have subsequently acquired the ability to control the expression of key 
      transcription factors that regulate CD8(+) T cell effector function and migratory 
      capacity.
FAU - Finlay, David
AU  - Finlay D
AD  - Division of Cell Biology and Immunology, University of Dundee, Dundee, UK.
FAU - Cantrell, Doreen A
AU  - Cantrell DA
LA  - eng
GR  - 065975/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
DEP - 20110114
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - *Cell Movement
MH  - Humans
MH  - *Immunologic Memory
MH  - Proto-Oncogene Proteins c-akt/*metabolism
MH  - T-Lymphocytes, Cytotoxic/*enzymology/*immunology
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC3521506
MID - EMS50767
OID - NLM: EMS50767
EDAT- 2011/01/15 06:00
MHDA- 2011/04/14 06:00
PMCR- 2012/12/13
CRDT- 2011/01/15 06:00
PHST- 2011/01/15 06:00 [entrez]
PHST- 2011/01/15 06:00 [pubmed]
PHST- 2011/04/14 06:00 [medline]
PHST- 2012/12/13 00:00 [pmc-release]
AID - nri2888 [pii]
AID - 10.1038/nri2888 [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2011 Feb;11(2):109-17. doi: 10.1038/nri2888. Epub 2011 Jan 14.