PMID- 21236447
OWN - NLM
STAT- MEDLINE
DCOM- 20110527
LR  - 20131121
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 302
IP  - 1-2
DP  - 2011 Mar 15
TI  - Proton magnetic resonance spectroscopy of the intrinsic tongue muscles in 
      patients with myasthenia gravis with different autoantibodies.
PG  - 25-8
LID - 10.1016/j.jns.2010.12.009 [doi]
AB  - OBJECTIVE: To assess lipid composition of the intrinsic tongue muscles in 
      patients with myasthenia gravis (MG). METHODS: This study included 15 MG patients 
      with antibodies against muscle-specific kinase (MuSK), 15 matched MG patients 
      with antibodies against acetylcholine receptor (AChR) and 15 matched healthy 
      subjects. Middle posterior region of the tongue was analyzed by single voxel 
      point-resolved proton magnetic resonance spectroscopy (MRS) using 1.5T MRI 
      scanner. RESULTS: MRS obtained from subject with AChR MG showed a broad resonance 
      arising from methylene groups of lipids (PMN) with no observable shoulder 
      attributed to methyl groups (PML). Full-width at half maximum (FWHM) of PMN+PML 
      peak showed higher value in patients with AChR MG in comparison to healthy 
      subjects and MuSK MG patients (p<0.05). In patients with MuSK MG, the shape and 
      FWHM of PMN+PML peak was similar as in healthy subjects (p>0.05), with tendency 
      toward increased ratio between PMN and resonance from vinyl protons of lipids 
      (PV). In both AChR and MuSK MG, total creatine resonance 
      (creatine+phosphocreatine, CP) was almost absent with significant increase of 
      PMN/CP ratio in comparison to healthy subjects (p<0.05). CONCLUSION: MRS is 
      useful in revealing muscle lipid composition in MG. In patients with AChR MG, MRS 
      showed increased lipid content in the tongue muscles due to the lipid migration 
      from intra- to extramyocellular space. Finding in patients with MuSK MG might 
      reflect intramyocellular lipid deposition in the tongue. CP decrease in tongue 
      muscles indicated impairment of oxidative metabolism in both AChR MG and MuSK MG.
CI  - Copyright (c) 2010. Published by Elsevier B.V.
FAU - Lavrnic, Dragana
AU  - Lavrnic D
AD  - Institute of Neurology, Clinical Center of Serbia, School of Medicine, University 
      of Belgrade, Belgrade, Serbia. dragana.lav@sbb.rs
FAU - Dakovic, Marko
AU  - Dakovic M
FAU - Peric, Stojan
AU  - Peric S
FAU - Rakocevic-Stojanovic, Vidosava
AU  - Rakocevic-Stojanovic V
FAU - Basta, Ivana
AU  - Basta I
FAU - Marjanovic, Ivan
AU  - Marjanovic I
FAU - Stosic-Opincal, Tatjana
AU  - Stosic-Opincal T
FAU - Lavrnic, Slobodan
AU  - Lavrnic S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110113
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Autoantibodies)
RN  - 0 (Lipids)
RN  - 0 (Receptors, Cholinergic)
RN  - 020IUV4N33 (Phosphocreatine)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - MU72812GK0 (Creatine)
SB  - IM
MH  - Adult
MH  - Autoantibodies/*analysis
MH  - Body Mass Index
MH  - Creatine/metabolism
MH  - Female
MH  - Humans
MH  - Lipids/chemistry
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/enzymology/*pathology
MH  - Myasthenia Gravis/enzymology/*immunology/*pathology
MH  - Phosphocreatine/metabolism
MH  - Protein-Tyrosine Kinases/metabolism
MH  - Receptors, Cholinergic/metabolism
MH  - Tongue/*pathology
EDAT- 2011/01/18 06:00
MHDA- 2011/05/28 06:00
CRDT- 2011/01/18 06:00
PHST- 2010/09/08 00:00 [received]
PHST- 2010/12/10 00:00 [revised]
PHST- 2010/12/13 00:00 [accepted]
PHST- 2011/01/18 06:00 [entrez]
PHST- 2011/01/18 06:00 [pubmed]
PHST- 2011/05/28 06:00 [medline]
AID - S0022-510X(10)00610-6 [pii]
AID - 10.1016/j.jns.2010.12.009 [doi]
PST - ppublish
SO  - J Neurol Sci. 2011 Mar 15;302(1-2):25-8. doi: 10.1016/j.jns.2010.12.009. Epub 
      2011 Jan 13.