PMID- 21239159
OWN - NLM
STAT- MEDLINE
DCOM- 20110606
LR  - 20161125
IS  - 1873-4235 (Electronic)
IS  - 0956-5663 (Linking)
VI  - 26
IP  - 7
DP  - 2011 Mar 15
TI  - A prototype of giant magnetoimpedance-based biosensing system for targeted 
      detection of gastric cancer cells.
PG  - 3246-53
LID - 10.1016/j.bios.2010.12.034 [doi]
AB  - A targeted detection of gastric cancer cells is achieved by combining the giant 
      magnetoimpedance (GMI)-based biosensing system and RGD-4C peptide coupled, 
      chitosan covered superparamagnetic iron oxide particles (RGD-Fe(3)O(4)@chitosan). 
      The micro-patterned GMI sensor for targeted detection is made of Co-based ribbon 
      and fabricated by micro electromechanical system (MEMS) technology. 
      Functionalized nanoparticles were designed by coating Fe(3)O(4) with chitosan and 
      conjugating with RGD-4C peptides. The targeted cells were trickled down into the 
      detection area of the system. The detection of each sample is carried out in 
      ten-fold manner and average value is taken as the final result. This system can 
      identify the differences between targeted cells and non-targeted cells. It is of 
      considerable interest due to its potential application in the biomedical field of 
      various specific detections.
CI  - Copyright (c) 2010 Elsevier B.V. All rights reserved.
FAU - Chen, Lei
AU  - Chen L
AD  - National Key Laboratory of Nano/Micro Fabrication Technology, Institute of Micro 
      and Nano Science and Technology, Shanghai Jiao Tong University, Shanghai, China. 
      leon_chen@sjtu.edu.cn
FAU - Bao, Chen-Chen
AU  - Bao CC
FAU - Yang, Hao
AU  - Yang H
FAU - Li, Ding
AU  - Li D
FAU - Lei, Chong
AU  - Lei C
FAU - Wang, Tao
AU  - Wang T
FAU - Hu, Heng-Yao
AU  - Hu HY
FAU - He, Meng
AU  - He M
FAU - Zhou, Yong
AU  - Zhou Y
FAU - Cui, Da-Xiang
AU  - Cui DX
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20101229
PL  - England
TA  - Biosens Bioelectron
JT  - Biosensors & bioelectronics
JID - 9001289
RN  - 0 (Ferric Compounds)
RN  - 0 (Oligopeptides)
RN  - 1K09F3G675 (ferric oxide)
RN  - 78VO7F77PN (arginyl-glycyl-aspartic acid)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Biosensing Techniques/*instrumentation
MH  - Cell Line
MH  - *Chitosan/chemistry
MH  - Equipment Design
MH  - *Ferric Compounds/chemistry
MH  - Humans
MH  - Magnetics/*instrumentation
MH  - *Nanoparticles/chemistry/ultrastructure
MH  - *Oligopeptides/chemistry
MH  - Stomach Neoplasms/*diagnosis
EDAT- 2011/01/18 06:00
MHDA- 2011/06/07 06:00
CRDT- 2011/01/18 06:00
PHST- 2010/09/30 00:00 [received]
PHST- 2010/12/13 00:00 [revised]
PHST- 2010/12/21 00:00 [accepted]
PHST- 2011/01/18 06:00 [entrez]
PHST- 2011/01/18 06:00 [pubmed]
PHST- 2011/06/07 06:00 [medline]
AID - S0956-5663(10)00869-9 [pii]
AID - 10.1016/j.bios.2010.12.034 [doi]
PST - ppublish
SO  - Biosens Bioelectron. 2011 Mar 15;26(7):3246-53. doi: 10.1016/j.bios.2010.12.034. 
      Epub 2010 Dec 29.