PMID- 21241546
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110118
IS  - 1009-3419 (Print)
IS  - 1009-3419 (Linking)
VI  - 7
IP  - 4
DP  - 2004 Aug 20
TI  - [Gefitinib is active in patients with brain metastasis from non-small cell lung 
      cancer].
PG  - 298-304
LID - 10.3779/j.issn.1009-3419.2004.04.07 [doi]
AB  - BACKGROUND: To explore the efficacy of gefitinib to non small cell lung cancer 
      (NSCLC) patients irrespective of their performance status, number of prior 
      treatment regimens and the presence of brain metastasis. METHODS: A total of 76 
      patients were enrolled. RESULTS: For all enrolled patients, the disease control 
      rate was 63.2% (95% CI, 52.1%-74.3%) with a median progression-free survival of 
      5.0 months (95% CI, 3.5-6.6 months) and median overall survival of 9.9 months 
      (95% CI, 4.9-14.8 months). Fifty seven patients had measurable lesions and the 
      objective response rate was 33.3% (95% CI, 20.7%-46.0%). Twenty one patients had 
      simultaneously assessable intracranial and extracranial lesions, 17 of them 
      (81.0%) showed comparable tumor response. There was no survival difference 
      between the patients with and without metastatic brain disease. Most drug-related 
      adverse events were mild. Intolerable toxicities happened in 5 patients, 4 of 
      them were interstitial pneumonia (5.8%) CONCLUSIONS: Gefitinib is active in 
      patients with brain metastasis from NSCLC. It is feasible to conduct randomized 
      trials to identify the role of gefitinib alone or in combination with other 
      modality in the treatment of NSCLC patients who have metastatic brain lesion(s).
FAU - Tsai, Chunming
AU  - Tsai C
AD  - Section of Thoracic Oncology, Chest Department, Taipei Veterans General Hospital, 
      Taipei, Taiwan, China.
FAU - Chiu, Chaohua
AU  - Chiu C
FAU - Liou, Jialing
AU  - Liou J
FAU - Tsai, Peijiun
AU  - Tsai P
FAU - Perng, Reuryperng
AU  - Perng R
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Fei Ai Za Zhi
JT  - Zhongguo fei ai za zhi = Chinese journal of lung cancer
JID - 101126433
EDAT- 2004/08/20 00:00
MHDA- 2004/08/20 00:01
CRDT- 2011/01/19 06:00
PHST- 2011/01/19 06:00 [entrez]
PHST- 2004/08/20 00:00 [pubmed]
PHST- 2004/08/20 00:01 [medline]
AID - 10.3779/j.issn.1009-3419.2004.04.07 [doi]
PST - ppublish
SO  - Zhongguo Fei Ai Za Zhi. 2004 Aug 20;7(4):298-304. doi: 
      10.3779/j.issn.1009-3419.2004.04.07.