PMID- 21241549
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110118
IS  - 1009-3419 (Print)
IS  - 1009-3419 (Linking)
VI  - 7
IP  - 4
DP  - 2004 Aug 20
TI  - [The salvage regimen for patients with advanced non-small cell lung cancer who 
      failed prior chemotherapy: once-daily single oral agent Iressa].
PG  - 313-7
LID - 10.3779/j.issn.1009-3419.2004.04.10 [doi]
AB  - BACKGROUND: To summarize the effect of Iressa for refractory patients with 
      advanced non small cell lung cancer (NSCLC) failed to prior chemotherapy. 
      METHODS: Thirty-one patients, with unresectable stage IIIB or IV NSCLC who had 
      disease progression or relapse after prior chemotherapy using platinum-based 
      regimen for at least 2 cycles, were admitted to the Osaka Prefectural Hobikino 
      Hospital. Iressa 250 mg was administered once a day until disease progression was 
      noted. Weekly chest x-ray and monthly CT scan were performed for response 
      assessment each month. RESULTS: Among the 31 patients, one complete response (CR) 
      and 7 partial responses (PR) were observed. CR rate was 3.2% (95% confidence 
      interval: 0-17%), PR rate 22.6% (95% confidence interval: 10%-41%), disease 
      control rate including both tumor responses and stable disease was 80.6% (95% 
      confidence interval: 52%-92%). The rate of symptoms relieves was 51.6% (95% 
      confidence interval: 33%-70%), the most effective symptoms being cough and pain. 
      The median time to improved symptoms was 14 days. The most common adverse events 
      were grade I or II skin rash and diarrhea which were readily manageable and 
      reversible. No patients were withdrawn due to the adverse events CONCLUSIONS: 
      Monotherapy using Iressa is effective and tolerable for the patients with 
      advanced NSCLC who failed prior chemotherapy.
FAU - Zheng, Di
AU  - Zheng D
AD  - Shanghai Pneumology Hospital, Shanghai 200433, P.R.China.
FAU - Yamadori, Tadahiro
AU  - Yamadori T
FAU - Hirashima, Tomonori
AU  - Hirashima T
FAU - Uryu, Kiyoaki
AU  - Uryu K
FAU - Matui, Kaoru
AU  - Matui K
FAU - Nitta, Takashi
AU  - Nitta T
FAU - Kobayashi, Masashi
AU  - Kobayashi M
FAU - Sasada, Shinji
AU  - Sasada S
FAU - Takimoto, Noriyuki
AU  - Takimoto N
FAU - Furukawa, Mitsugu
AU  - Furukawa M
FAU - Ooba, Yuichirou
AU  - Ooba Y
FAU - Zhou, Caicun
AU  - Zhou C
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Fei Ai Za Zhi
JT  - Zhongguo fei ai za zhi = Chinese journal of lung cancer
JID - 101126433
EDAT- 2004/08/20 00:00
MHDA- 2004/08/20 00:01
CRDT- 2011/01/19 06:00
PHST- 2011/01/19 06:00 [entrez]
PHST- 2004/08/20 00:00 [pubmed]
PHST- 2004/08/20 00:01 [medline]
AID - 10.3779/j.issn.1009-3419.2004.04.10 [doi]
PST - ppublish
SO  - Zhongguo Fei Ai Za Zhi. 2004 Aug 20;7(4):313-7. doi: 
      10.3779/j.issn.1009-3419.2004.04.10.