PMID- 21241551
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110118
IS  - 1009-3419 (Print)
IS  - 1009-3419 (Linking)
VI  - 7
IP  - 4
DP  - 2004 Aug 20
TI  - [Iressa for the non-small cell lung cancer patients who failed prior chemotherapy 
      and radiotherapy].
PG  - 321-4
LID - 10.3779/j.issn.1009-3419.2004.04.12 [doi]
AB  - BACKGROUND: To summarize the clinical results of Iressa in the treatment of 
      patients with non small cell lung cancer (NSCLC) who failed prior chemotherapy 
      and radiotherapy. METHODS: Twenty-nine patients with NSCLC, who failed prior 
      chemotherapy and radiotherapy, were registered in this open clinical trial. Prior 
      to Iressa therapy, 26 patients were in stage IV, 3 patients in stage IIIB. Iressa 
      was administered orally at 250 mg, once a day until cancer progressed or severe 
      toxicity occured. The median time for administration of Iressa was 5 months. 
      RESULTS: The main toxicity of Iressa was skin toxicity (rash). Twelve cases had 
      rash with 41.4% of the whole group. Two cases had diarrhea, 1 case had 
      bradycardia and 1 case had elevation of transaminase. Among the 29 patients, one 
      patient got complete response (CR), 7 partial response (PR), 12 stable disease 
      (SD) and 9 progression disease (PD). The response rate was 27.59% and disease 
      control rate including both tumor response and stable disease was 68.97%. The 
      median survival time was 5.5 months (1-19 months). Median time to progression 
      (TTP) was 6.5 months. The 1-year survival rate was 44.83%. CONCLUSIONS: Iressa is 
      effective and tolerable for the patients with NSCLC who failed prior chemotherapy 
      and radiotherapy. It can remarkably improve symptoms and prolong survival time of 
      NSCLC patients.
FAU - Liu, Lunxu
AU  - Liu L
AD  - Department of Thoracic Surgery, Respiratory Medicine and Cancer Center, West 
      China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China.
FAU - Li, Weimin
AU  - Li W
FAU - Li, Lu
AU  - Li L
FAU - Li, Juan
AU  - Li J
FAU - Zhou, Qinghua
AU  - Zhou Q
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Fei Ai Za Zhi
JT  - Zhongguo fei ai za zhi = Chinese journal of lung cancer
JID - 101126433
EDAT- 2004/08/20 00:00
MHDA- 2004/08/20 00:01
CRDT- 2011/01/19 06:00
PHST- 2011/01/19 06:00 [entrez]
PHST- 2004/08/20 00:00 [pubmed]
PHST- 2004/08/20 00:01 [medline]
AID - 10.3779/j.issn.1009-3419.2004.04.12 [doi]
PST - ppublish
SO  - Zhongguo Fei Ai Za Zhi. 2004 Aug 20;7(4):321-4. doi: 
      10.3779/j.issn.1009-3419.2004.04.12.