PMID- 21241556
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110118
IS  - 1009-3419 (Print)
IS  - 1009-3419 (Linking)
VI  - 7
IP  - 4
DP  - 2004 Aug 20
TI  - [Different expressions of p53 gene family members and their clinical significance 
      in human non-small cell lung cancer].
PG  - 339-43
LID - 10.3779/j.issn.1009-3419.2004.04.17 [doi]
AB  - BACKGROUND: To investigate the different expressions of p53 gene family members 
      p53, p63 and p73, and their clinical significance in non small cell lung cancer 
      (NSCLC). METHODS: p53, p63 and p73 protein expressions were detected in 60 NSCLC 
      tissues and 7 normal lung tissues by immunohistochemistry. RESULTS: In NSCLC, 
      positive rate of p53, p63 and p73 protein was 61.67%(37/60), 80.00%(48/60), 
      73.33% (44/60) respectively. There were significant differences in positive rate 
      of three proteins as compared to normal lung tissue ( P < 0.05). p53 protein 
      expression was closely associated with tumor cell differentiation degree ( P 
      =0.023), but was not associated with histological classification, lymph node 
      metastasis and clinical stages ( P > 0.05). Expression of p63 protein was closely 
      related to lymph node metastasis ( P =0.028) and histological classification ( P 
      =0.001), but not to cell differentiation degree and clinical stages ( P > 0.05). 
      There was no significant relationship between p73 protein expression and clinical 
      characteristics of NSCLC ( P > 0.05). A positive correlation was present between 
      p63 and p73 protein expressions ( P =0.000 1). No statistical correlation was 
      found between p53 and p73 ( P > 0.05). CONCLUSIONS: p53 gene family may be 
      related to the oncogenesis and development of NSCLC. p63 and p73 proteins may 
      have different biological function from p53 protein, and both might play 
      oncogenic roles.
FAU - Chen, Fuchun
AU  - Chen F
AD  - Department of Thoracosurgery, Traditional Chinese Medical Hospital of Wenling, 
      Wenling, Zhejiang 317500, P.R.China.
FAU - Chen, Honglei
AU  - Chen H
FAU - Tao, Hongchao
AU  - Tao H
FAU - Zhang, Yuxia
AU  - Zhang Y
FAU - Ye, Bo
AU  - Ye B
FAU - Liu, Mingqiu
AU  - Liu M
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Fei Ai Za Zhi
JT  - Zhongguo fei ai za zhi = Chinese journal of lung cancer
JID - 101126433
EDAT- 2004/08/20 00:00
MHDA- 2004/08/20 00:01
CRDT- 2011/01/19 06:00
PHST- 2011/01/19 06:00 [entrez]
PHST- 2004/08/20 00:00 [pubmed]
PHST- 2004/08/20 00:01 [medline]
AID - 10.3779/j.issn.1009-3419.2004.04.17 [doi]
PST - ppublish
SO  - Zhongguo Fei Ai Za Zhi. 2004 Aug 20;7(4):339-43. doi: 
      10.3779/j.issn.1009-3419.2004.04.17.