PMID- 21241672
OWN - NLM
STAT- MEDLINE
DCOM- 20110722
LR  - 20221207
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1381
DP  - 2011 Mar 24
TI  - Interleukin-18 promoter polymorphisms and risk of Parkinson's disease in a Han 
      Chinese population.
PG  - 90-4
LID - 10.1016/j.brainres.2011.01.025 [doi]
AB  - The etiology of sporadic Parkinson's disease (PD) is not well established. 
      Interleukin-18 (IL-18), a member of pro-inflammatory cytokines, might influence 
      the risk of sporadic PD occurrence and development. In this study, two DNA 
      polymorphisms at interleukin (IL)-18 promoter, -607C/A (rs1946518) and -137G/C 
      (rs187238), were examined in sporadic PD patients in a Han Chinese population 
      with 290 sporadic PD patients and 200 healthy controls. Direct sequencing was 
      performed in 10% of the samples to validate the genotyping results. The results 
      revealed that for -607C/A polymorphisms, there were significant differences in 
      genotype distribution between PD and control in the total sample (P=0.017) and 
      between LOPD and healthy-matched controls subgroup (P=0.011). For -137G/C 
      polymorphisms, there were no significant differences in genotype distribution and 
      gender and age-related differences between PD and control in the total sample 
      (P=0.610). Results in this study revealed that the IL-18 607C/A polymorphism is a 
      risk factor for sporadic LOPD in Han Chinese population, while IL-18 137G/C 
      polymorphism is not a risk factor for sporadic PD in the Han Chinese population.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Xu, Xiang
AU  - Xu X
AD  - Department of Neurology, Affiliated Hospital of Medical College, Qingdao 
      University, Qingdao, PR China.
FAU - Li, Dequan
AU  - Li D
FAU - He, Qing
AU  - He Q
FAU - Gao, Jing
AU  - Gao J
FAU - Chen, Biao
AU  - Chen B
FAU - Xie, Anmu
AU  - Xie A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110115
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Aged
MH  - Alleles
MH  - Asian People/genetics
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/*genetics
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic/*genetics
MH  - Risk Factors
EDAT- 2011/01/19 06:00
MHDA- 2011/07/23 06:00
CRDT- 2011/01/19 06:00
PHST- 2010/08/19 00:00 [received]
PHST- 2010/12/19 00:00 [revised]
PHST- 2011/01/10 00:00 [accepted]
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2011/07/23 06:00 [medline]
AID - S0006-8993(11)00061-8 [pii]
AID - 10.1016/j.brainres.2011.01.025 [doi]
PST - ppublish
SO  - Brain Res. 2011 Mar 24;1381:90-4. doi: 10.1016/j.brainres.2011.01.025. Epub 2011 
      Jan 15.