PMID- 21241757
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20161125
IS  - 1872-8294 (Electronic)
IS  - 0169-409X (Linking)
VI  - 63
IP  - 8
DP  - 2011 Jul 18
TI  - Regulatory systems for hypoxia-inducible gene expression in ischemic heart 
      disease gene therapy.
PG  - 678-87
LID - 10.1016/j.addr.2011.01.003 [doi]
AB  - Ischemic heart diseases are caused by narrowed coronary arteries that decrease 
      the blood supply to the myocardium. In the ischemic myocardium, 
      hypoxia-responsive genes are up-regulated by hypoxia-inducible factor-1 (HIF-1). 
      Gene therapy for ischemic heart diseases uses genes encoding angiogenic growth 
      factors and anti-apoptotic proteins as therapeutic genes. These genes increase 
      blood supply into the myocardium by angiogenesis and protect cardiomyocytes from 
      cell death. However, non-specific expression of these genes in normal tissues may 
      be harmful, since growth factors and anti-apoptotic proteins may induce tumor 
      growth. Therefore, tight gene regulation is required to limit gene expression to 
      ischemic tissues, to avoid unwanted side effects. For this purpose, various gene 
      expression strategies have been developed for ischemic-specific gene expression. 
      Transcriptional, post-transcriptional, and post-translational regulatory 
      strategies have been developed and evaluated in ischemic heart disease animal 
      models. The regulatory systems can limit therapeutic gene expression to ischemic 
      tissues and increase the efficiency of gene therapy. In this review, recent 
      progresses in ischemic-specific gene expression systems are presented, and their 
      applications to ischemic heart diseases are discussed.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Kim, Hyun Ah
AU  - Kim HA
AD  - Department of Bioengineering, College of Engineering, Hanyang University, Seoul 
      133-791, Republic of Korea.
FAU - Rhim, Taiyoun
AU  - Rhim T
FAU - Lee, Minhyung
AU  - Lee M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110115
PL  - Netherlands
TA  - Adv Drug Deliv Rev
JT  - Advanced drug delivery reviews
JID - 8710523
RN  - 0 (Hypoxia-Inducible Factor 1)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - *Gene Expression Regulation
MH  - Genetic Therapy/*methods
MH  - Humans
MH  - Hypoxia/genetics
MH  - Hypoxia-Inducible Factor 1/genetics/metabolism
MH  - Myocardial Ischemia/physiopathology/*therapy
EDAT- 2011/01/19 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/01/19 06:00
PHST- 2010/11/15 00:00 [received]
PHST- 2010/12/29 00:00 [revised]
PHST- 2011/01/05 00:00 [accepted]
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - S0169-409X(11)00007-X [pii]
AID - 10.1016/j.addr.2011.01.003 [doi]
PST - ppublish
SO  - Adv Drug Deliv Rev. 2011 Jul 18;63(8):678-87. doi: 10.1016/j.addr.2011.01.003. 
      Epub 2011 Jan 15.