PMID- 21242015
OWN - NLM
STAT- MEDLINE
DCOM- 20120217
LR  - 20120604
IS  - 1618-1298 (Electronic)
IS  - 0171-9335 (Linking)
VI  - 90
IP  - 11
DP  - 2011 Nov
TI  - Structural insights into Met receptor activation.
PG  - 972-81
LID - 10.1016/j.ejcb.2010.11.014 [doi]
AB  - The receptor tyrosine kinase Met plays a pivotal role in vertebrate development 
      and tissue regeneration, its deregulation contributes to cancer. Met is also 
      targeted during the infection by the facultative intracellular bacterium Listeria 
      monocytogenes. The mechanistic basis for Met activation by its natural ligand 
      hepatocyte growth factor/scatter factor (HGF/SF) is only beginning to be 
      understood at a structural level. Crystal structures of Met in complex with L. 
      monocytogenes InlB suggest that Met dimerization by this bacterial invasion 
      protein is mediated by a dimer contact of the ligand. Here, I review the 
      structural basis of Met activation by InlB and highlight parallels and 
      differences to the physiological Met ligand HGF/SF and its splice variant NK1.
CI  - Copyright (c) 2010 Elsevier GmbH. All rights reserved.
FAU - Niemann, Hartmut H
AU  - Niemann HH
AD  - Department of Chemistry, Bielefeld University, Universitatsstrasse 25, 33615 
      Bielefeld, Germany. Hartmut.Niemann@uni-bielefeld.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110115
PL  - Germany
TA  - Eur J Cell Biol
JT  - European journal of cell biology
JID - 7906240
RN  - 0 (Bacterial Proteins)
RN  - 0 (Ligands)
RN  - 0 (Membrane Proteins)
RN  - 0 (inlB protein, Listeria monocytogenes)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (MET protein, human)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Animals
MH  - Bacterial Proteins/metabolism
MH  - Cell Differentiation
MH  - Hepatocyte Growth Factor/chemistry/metabolism
MH  - Humans
MH  - Ligands
MH  - Listeria monocytogenes/metabolism
MH  - Membrane Proteins/metabolism
MH  - Protein Binding
MH  - Protein Multimerization
MH  - Proto-Oncogene Proteins c-met/*chemistry/*metabolism
EDAT- 2011/01/19 06:00
MHDA- 2012/02/18 06:00
CRDT- 2011/01/19 06:00
PHST- 2010/08/26 00:00 [received]
PHST- 2010/11/24 00:00 [revised]
PHST- 2010/11/25 00:00 [accepted]
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2012/02/18 06:00 [medline]
AID - S0171-9335(10)00264-5 [pii]
AID - 10.1016/j.ejcb.2010.11.014 [doi]
PST - ppublish
SO  - Eur J Cell Biol. 2011 Nov;90(11):972-81. doi: 10.1016/j.ejcb.2010.11.014. Epub 
      2011 Jan 15.