PMID- 21242642
OWN - NLM
STAT- MEDLINE
DCOM- 20110707
LR  - 20190819
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 75
IP  - 3
DP  - 2011
TI  - Synergistic effect of combined HMG-CoA reductase inhibitor and angiotensin-II 
      receptor blocker therapy in patients with chronic heart failure: the HF-COSTAR 
      trial.
PG  - 589-95
AB  - BACKGROUND: It is known that HMG-CoA reductase inhibitors (statins) may have a 
      therapeutic benefit in patients with heart failure (HF). However, no studies have 
      yet evaluated the possible interaction of statins and angiotensin-II receptor 
      blockers (ARBs) on left ventricular (LV) function in patients with HF. We 
      hypothesized that statins might alter the effect of ARBs on cardiac function in 
      patients with HF. METHODS AND RESULTS: We prospectively randomized patients with 
      chronic HF who received the ARB, losartan (LOS group), or the statin, simvastatin 
      (SIM), in combination with LOS (SIM+LOS group) at our hospitals and assessed 
      before and after treatment for 6 months. Although no significant improvement of 
      HF symptoms as evaluated by the New York Heart Association (NYHA) classification 
      was observed in the LOS group, HF symptoms in the SIM+LOS group significantly 
      improved. The percent increase of LV ejection fraction after treatment in the 
      SIM+LOS group was significantly larger than in the LOS group. Furthermore, the 
      plasma brain natriuretic peptide level was significantly lower after treatment in 
      the SIM+LOS group than in the LOS group. CONCLUSIONS: Combined statin and ARB 
      therapy significantly improves both symptoms and LV function over time in 
      patients with HF. Thus, the combination of an ARB with a statin may be a useful 
      therapeutic strategy for HF.
FAU - Maejima, Yasuhiro
AU  - Maejima Y
AD  - Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 
      1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
FAU - Nobori, Kiyoshi
AU  - Nobori K
FAU - Ono, Yuichi
AU  - Ono Y
FAU - Adachi, Susumu
AU  - Adachi S
FAU - Suzuki, Jun-Ichi
AU  - Suzuki J
FAU - Hirao, Kenzo
AU  - Hirao K
FAU - Isobe, Mitsuaki
AU  - Isobe M
FAU - Ito, Hiroshi
AU  - Ito H
CN  - Heart Failure by Coadministration of Statin and Angiotensin-II Receptor Blocker 
      (HF-COSTAR) Trial Investigators
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20110114
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Angiotensin Receptor Antagonists)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - AGG2FN16EV (Simvastatin)
RN  - JMS50MPO89 (Losartan)
SB  - IM
CIN - Circ J. 2011;75(3):540-1. PMID: 21266784
MH  - Aged
MH  - Angiotensin Receptor Antagonists/pharmacology/*therapeutic use
MH  - Chronic Disease
MH  - Drug Synergism
MH  - Drug Therapy, Combination
MH  - Electrocardiography
MH  - Female
MH  - Heart Failure/*drug therapy/physiopathology
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology/*therapeutic use
MH  - Losartan/pharmacology/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Renin-Angiotensin System/drug effects/physiology
MH  - Simvastatin/pharmacology/*therapeutic use
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/drug therapy/physiopathology
FIR - Maejima, Yasuhiro
IR  - Maejima Y
FIR - Hirao, Kenzo
IR  - Hirao K
FIR - Isobe, Mitsuaki
IR  - Isobe M
FIR - Suzuki, Jun-ichi
IR  - Suzuki J
FIR - Adachi, Susumu
IR  - Adachi S
FIR - Takamoto, Toshihiko
IR  - Takamoto T
FIR - Hattori, Eijirou
IR  - Hattori E
FIR - Nanba, Kenichi
IR  - Nanba K
FIR - Ono, Yuichi
IR  - Ono Y
FIR - Kadowaki, Ken
IR  - Kadowaki K
FIR - Nakanishi, Toru
IR  - Nakanishi T
FIR - Terui, Gen
IR  - Terui G
FIR - Katsuta, Mitsuaki
IR  - Katsuta M
FIR - Suzuki, Yasushi
IR  - Suzuki Y
FIR - Nemoto, Toshifumi
IR  - Nemoto T
FIR - Nobori, Kiyoshi
IR  - Nobori K
FIR - Ishida, Masaru
IR  - Ishida M
FIR - Koyama, Takashi
IR  - Koyama T
FIR - Ito, Hiroshi
IR  - Ito H
EDAT- 2011/01/19 06:00
MHDA- 2011/07/08 06:00
CRDT- 2011/01/19 06:00
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2011/07/08 06:00 [medline]
AID - JST.JSTAGE/circj/CJ-10-0804 [pii]
AID - 10.1253/circj.cj-10-0804 [doi]
PST - ppublish
SO  - Circ J. 2011;75(3):589-95. doi: 10.1253/circj.cj-10-0804. Epub 2011 Jan 14.