PMID- 21243090 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211020 VI - 19 DP - 2005 Apr 4 TI - Comparison of Current BLAST Software on Nucleotide Sequences. PG - 8 AB - The computational power needed for searching exponentially growing databases, such as GenBank, has increased dramatically. Three different implementations of the most widely used sequence alignment tool, known as BLAST (Basic Local Alignment Search Tool), are studied for their efficiency on nucleotide-nucleotide comparisons. The performance of these implementations are evaluated using target databases and query sequences of varying lengths and number of entries constructed from human genomic and EST sequences. In general, WU BLAST was found to be most efficient when the database and query composition are unknown. NCBI BLAST appears to work best when the database contains a small number of sequences, while mpiBLAST shows the power of database distribution when the number of bases per target database is large. The optimal number of compute nodes in mpiBLAST varies depending upon the database, yet in the cases studied, remains surprisingly low. FAU - Elizabeth Cha, I AU - Elizabeth Cha I AD - University of Louisville Department of Computer Engineering and Computer Science, Louisville, KY 40292, icha@louisville.edu. FAU - Rouchka, Eric C AU - Rouchka EC LA - eng GR - P20 GM103436/GM/NIGMS NIH HHS/United States GR - P20 RR016481/RR/NCRR NIH HHS/United States GR - P20 RR016481-04/RR/NCRR NIH HHS/United States PT - Journal Article PL - United States TA - Proc IPDPS (Conf) JT - Proceedings. IPDPS (Conference) JID - 101602856 PMC - PMC3021256 MID - NIHMS137493 EDAT- 2005/04/04 00:00 MHDA- 2005/04/04 00:01 PMCR- 2011/01/14 CRDT- 2011/09/28 06:00 PHST- 2011/09/28 06:00 [entrez] PHST- 2005/04/04 00:00 [pubmed] PHST- 2005/04/04 00:01 [medline] PHST- 2011/01/14 00:00 [pmc-release] AID - 10.1109/IPDPS.2005.145 [doi] PST - ppublish SO - Proc IPDPS (Conf). 2005 Apr 4;19:8. doi: 10.1109/IPDPS.2005.145.