PMID- 21243279
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20220629
IS  - 1980-5322 (Electronic)
IS  - 1807-5932 (Print)
IS  - 1807-5932 (Linking)
VI  - 65
IP  - 11
DP  - 2010
TI  - Does minor histocompatibility antigen HA-1 disparity affect the occurrence of 
      graft-versus-host disease in tunisian recipients of hematopoietic stem cells?
PG  - 1099-103
AB  - INTRODUCTION: Minor histocompatibility antigen HA-1 (MiHAg-HA-1) disparity 
      between a patient and his or her human leukocyte antigen (HLA) genoidentical 
      donor has been widely associated with an increased risk of graft-versus-host 
      disease following allogeneic hematopoietic stem cell transplantation. OBJECTIVE: 
      To examine the effect of HA-1 disparity on the incidence of both acute and 
      chronic graft-versus-host disease in Tunisian recipients of hematopoietic stem 
      cells. METHODS: A total of 60 patients and their 60 respective sibling 
      hematopoietic stem cell donors were enrolled in this study. All patients 
      prophylactically received cyclosporine A and/or methotrexate for 
      graft-versus-host disease. An HA-1 genotyping assay was performed with the 
      SSP-PCR method, and HLA-A*0201- and/or HLA-A*0206-positive samples were 
      identified using the Luminex HLA typing method. RESULTS: The Luminex HLA typing 
      assay showed that 54 patients were positive for either the HLA-A*0201 or 
      HLA-A*0206 alleles. Among these cases, six pairs were mismatched for MiHAg-HA-1. 
      Both acute and chronic graft-versus-host disease occurred in four mismatched 
      patients (Fisher's p-values were 0.044 and 0.170, respectively). A univariate 
      logistic regression model analysis showed that only acute graft-versus-host 
      disease may be affected by recipient MiHAg-HA-1 disparity (p: 0.041, OR: 6.727), 
      while chronic graft-versus-host disease correlates with both age and 
      recipient/donor sex mismatch (p: 0.014, OR: 8.556 and p: 0.033, OR: 8.664, 
      respectively). CONCLUSION: Our findings support previously reported data 
      suggesting a significant association between HA-1 disparity and the risk of acute 
      graft-versus-host disease following hematopoietic stem cell transplantation.
FAU - Sellami, Mohamed Hichem
AU  - Sellami MH
AD  - HLA-Typing Department, National Blood Transfusion Centre of Tunis, Tunisia.
FAU - Torjemane, Lamia
AU  - Torjemane L
FAU - Arias, Alejandro Espadas de
AU  - Arias AE
FAU - Kaabi, Houda
AU  - Kaabi H
FAU - Ladeb, Saloua
AU  - Ladeb S
FAU - Poli, Francesca
AU  - Poli F
FAU - Othmane, Tarek Ben
AU  - Othmane TB
FAU - Hmida, Slama
AU  - Hmida S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clinics (Sao Paulo)
JT  - Clinics (Sao Paulo, Brazil)
JID - 101244734
RN  - 0 (HA-1 antigen)
RN  - 0 (HLA Antigens)
RN  - 0 (Minor Histocompatibility Antigens)
RN  - 0 (Oligopeptides)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Graft vs Host Disease/*immunology
MH  - HLA Antigens/*immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Minor Histocompatibility Antigens/genetics/*immunology
MH  - Oligopeptides/genetics/*immunology
MH  - Polymerase Chain Reaction
MH  - Risk Factors
MH  - Sex Factors
MH  - Tunisia
MH  - Young Adult
PMC - PMC2999702
EDAT- 2011/01/19 06:00
MHDA- 2011/10/15 06:00
PMCR- 2010/11/01
CRDT- 2011/01/19 06:00
PHST- 2010/07/02 00:00 [received]
PHST- 2010/07/26 00:00 [accepted]
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
PHST- 2010/11/01 00:00 [pmc-release]
AID - S1807-5932(22)02891-5 [pii]
AID - cln_65p1099 [pii]
AID - 10.1590/s1807-59322010001100007 [doi]
PST - ppublish
SO  - Clinics (Sao Paulo). 2010;65(11):1099-103. doi: 10.1590/s1807-59322010001100007.