PMID- 21243294
OWN - NLM
STAT- MEDLINE
DCOM- 20111014
LR  - 20220629
IS  - 1980-5322 (Electronic)
IS  - 1807-5932 (Print)
IS  - 1807-5932 (Linking)
VI  - 65
IP  - 11
DP  - 2010
TI  - The role of central mechanisms in the anti-inflammatory effect of amitriptyline 
      on carrageenan-induced paw edema in rats.
PG  - 1183-7
AB  - OBJECTIVE: The present study was designed to further investigate the effect of 
      amitriptyline, a classical tricyclic antidepressant, on carrageenan-induced paw 
      edema in rats. METHODS: First, amitriptyline was administered intraperitoneally 
      (i.p.) at doses of 20, 40 and 80 mg kg-1, 30 min before subplantar injection of 
      carrageenan. Second, amitriptyline was given intracerebroventriculary or 
      intrathecally at doses of 25, 50 and 100 mug/rat, 30 min prior to carrageenan 
      challenge. Third, the effect of adrenergic receptor antagonists such as 
      propranolol (10 mg kg-1, i.p.), prazosin (4 mg kg-1, i.p.) and yohimbine (10 mg 
      kg-1, i.p.) and an opioid receptor antagonist (naloxone, 4 mg kg-1, i.p.) on the 
      anti-inflammatory effect of amitriptyline (40 mg kg-1, i.p.) was investigated. 
      RESULTS: Our data confirm that intraperitoneally administered amitriptyline 
      exhibits a marked anti-inflammatory effect on carrageenan-induced paw edema in 
      rats 4 h postcarrageenan challenge (P < 0.001). Intracerebroventricular (i.c.v.) 
      administration of amitriptyline also reduced the development of paw edema at 4 h 
      postcarrageenan (P < 0.001), but intrathecal (i.t.) application of amitriptyline 
      failed to alter the degree of paw swelling. Furthermore, the applied antagonists 
      did not modify the anti-inflammatory effect of amitriptyline. CONCLUSION: These 
      results support the view that amitriptyline has a considerable anti-inflammatory 
      effect on carrageenan-induced paw edema in rats and suggest that at least a part 
      of this property could be mediated through supraspinal sites. Moreover, it seems 
      unlikely that the investigated adrenergic and opioid receptors have a significant 
      role in this effect of amitriptyline.
FAU - Hajhashemi, Valiollah
AU  - Hajhashemi V
AD  - Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and 
      Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
FAU - Sadeghi, Hossein
AU  - Sadeghi H
FAU - Minaiyan, Mohsen
AU  - Minaiyan M
FAU - Movahedian, Ahmad
AU  - Movahedian A
FAU - Talebi, Ardeshir
AU  - Talebi A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clinics (Sao Paulo)
JT  - Clinics (Sao Paulo, Brazil)
JID - 101244734
RN  - 0 (Adrenergic alpha-1 Receptor Antagonists)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 1806D8D52K (Amitriptyline)
RN  - 9000-07-1 (Carrageenan)
SB  - IM
MH  - Adrenergic alpha-1 Receptor Antagonists/*administration & dosage
MH  - Amitriptyline/*administration & dosage
MH  - Animals
MH  - Anti-Inflammatory Agents/*administration & dosage
MH  - Carrageenan
MH  - Edema/chemically induced/*drug therapy
MH  - Inflammation/chemically induced/drug therapy
MH  - Injections, Spinal
MH  - Male
MH  - Rats
MH  - Rats, Wistar
PMC - PMC2999717
EDAT- 2011/01/19 06:00
MHDA- 2011/10/15 06:00
PMCR- 2010/11/01
CRDT- 2011/01/19 06:00
PHST- 2010/04/07 00:00 [received]
PHST- 2010/08/26 00:00 [accepted]
PHST- 2011/01/19 06:00 [entrez]
PHST- 2011/01/19 06:00 [pubmed]
PHST- 2011/10/15 06:00 [medline]
PHST- 2010/11/01 00:00 [pmc-release]
AID - S1807-5932(22)02906-4 [pii]
AID - cln_65p1183 [pii]
AID - 10.1590/s1807-59322010001100022 [doi]
PST - ppublish
SO  - Clinics (Sao Paulo). 2010;65(11):1183-7. doi: 10.1590/s1807-59322010001100022.