PMID- 21245159
OWN - NLM
STAT- MEDLINE
DCOM- 20111027
LR  - 20220317
IS  - 1569-8041 (Electronic)
IS  - 0923-7534 (Linking)
VI  - 22
IP  - 7
DP  - 2011 Jul
TI  - No improvement of survival with reduced- versus high-intensity conditioning for 
      allogeneic stem cell transplants in Ewing tumor patients.
PG  - 1614-1621
LID - S0923-7534(19)38449-2 [pii]
LID - 10.1093/annonc/mdq703 [doi]
AB  - BACKGROUND: Outcomes of Ewing tumor (ET) patients treated with allogeneic stem 
      cell transplantation (allo-SCT) were compared regarding the use of 
      reduced-intensity conditioning (RIC) and high-intensity conditioning (HIC) 
      regimens as well as human leukocyte antigen (HLA)-matched and HLA-mismatched 
      grafts. PATIENTS AND METHODS: We retrospectively analyzed data of 87 ET patients 
      from the European Group for Blood and Marrow Transplantation, Pediatric Registry 
      for Stem Cell Transplantations, Asia Pacific Blood and Marrow Transplantation and 
      MetaEICESS registries treated with allo-SCT. Fifty patients received RIC (group 
      A) and 37 patients received HIC (group B). Twenty-four patients received 
      HLA-mismatched grafts and 63 received HLA-matched grafts. RESULTS: Median overall 
      survival was 7.9 months [+/-1.24, 95% confidence interval (CI) 5.44-10.31] for 
      group A and 4.4 months (+/-1.06, 95% CI 2.29-6.43) for group B patients (P = 1.3). 
      Death of complications (DOC) occurred in 4 of 50 (0.08) and death of disease 
      (DOD) in 33 of 50 (0.66) group A and in 16 of 37 (0.43) and 17 of 37 (0.46) group 
      B patients, respectively. DOC incidence was decreased (P < 0.01) and DOD/relapse 
      increased (P < 0.01) in group A compared with group B. HLA mismatch was not 
      generally associated with graft-versus-Ewing tumor effect (GvETE). CONCLUSIONS: 
      There was no improvement of survival with RIC compared with HIC due to increased 
      DOD/relapse incidence after RIC despite less DOC incidence. This implicates 
      general absence of a clinically relevant GvETE with current protocols.
FAU - Thiel, U
AU  - Thiel U
AD  - Department of Pediatrics and Wilhelm Sander Sarcoma Unit MRI, Pediatric Oncology 
      Center, Technische Universitat Munchen.
FAU - Wawer, A
AU  - Wawer A
AD  - Department of Pediatrics and Wilhelm Sander Sarcoma Unit MRI, Pediatric Oncology 
      Center, Technische Universitat Munchen.
FAU - Wolf, P
AU  - Wolf P
AD  - Institute for Medical Statistics and Epidemiology, Klinikum rechts der Isar der 
      Technischen Universitat Munchen, Munich, Germany.
FAU - Badoglio, M
AU  - Badoglio M
AD  - EBMT Data & Study Office, Hopital Saint-Antoine, Assistance Publique des Hopitaux 
      de Paris and UPMC Univ Paris 06, Paris, France.
FAU - Santucci, A
AU  - Santucci A
AD  - Section of Pediatric Hematology & Oncology, University of Perugia, Perugia, 
      Italy.
FAU - Klingebiel, T
AU  - Klingebiel T
AD  - Children's Hospital III, Department of Pediatrics, Johann Wolfgang Goethe 
      University, Frankfurt.
FAU - Basu, O
AU  - Basu O
AD  - Children's Hospital III, Department of Pediatrics, Johann Wolfgang Goethe 
      University, Frankfurt.
FAU - Borkhardt, A
AU  - Borkhardt A
AD  - Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich 
      Heine University, Dusseldorf, Germany.
FAU - Laws, H-J
AU  - Laws HJ
AD  - Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich 
      Heine University, Dusseldorf, Germany.
FAU - Kodera, Y
AU  - Kodera Y
AD  - Department of Promotion for Blood and Marrow Transplantation, Aichi Medical 
      University, Aichi; APBMT Data Center, Nagoya University School of Medicine, 
      Nagoya, Japan.
FAU - Yoshimi, A
AU  - Yoshimi A
AD  - APBMT Data Center, Nagoya University School of Medicine, Nagoya, Japan.
FAU - Peters, C
AU  - Peters C
AD  - Department of Pediatrics, St. Anna Kinderspital, Vienna, Austria.
FAU - Ladenstein, R
AU  - Ladenstein R
AD  - Department of Pediatrics, St. Anna Kinderspital, Vienna, Austria.
FAU - Pession, A
AU  - Pession A
AD  - Department of Scienze Pediatriche Mediche e Chirurgiche, Ospedale S Orsola 
      Malpighi, Bologna, Italy.
FAU - Prete, A
AU  - Prete A
AD  - Department of Scienze Pediatriche Mediche e Chirurgiche, Ospedale S Orsola 
      Malpighi, Bologna, Italy.
FAU - Urban, E-C
AU  - Urban EC
AD  - Department of Pediatrics, Medical University of Graz, Graz, Austria.
FAU - Schwinger, W
AU  - Schwinger W
AD  - Department of Pediatrics, Medical University of Graz, Graz, Austria.
FAU - Bordigoni, P
AU  - Bordigoni P
AD  - Service de Transplantation Medullaire, CHU de Nancy Brabois, 
      Vandoeuvre-les-Nancy, France.
FAU - Salmon, A
AU  - Salmon A
AD  - Service de Transplantation Medullaire, CHU de Nancy Brabois, 
      Vandoeuvre-les-Nancy, France.
FAU - Diaz, M A
AU  - Diaz MA
AD  - Department of Pediatrics, Division of Pediatric Hematology-Oncology and 
      Hematopoietic Stem Cell Transplantation and Cell Therapy Unit, Hospital Infantil 
      Universitario Nino Jesus, Madrid, Spain.
FAU - Afanasyev, B
AU  - Afanasyev B
AD  - St. Petersburg State Medical Pavlov University, Ratsa Gorbacheva Memorial 
      Children;s Institute, Department of Hematology and Transplantology, St. 
      Petersburg, Russia.
FAU - Lisukov, I
AU  - Lisukov I
AD  - St. Petersburg State Medical Pavlov University, Ratsa Gorbacheva Memorial 
      Children;s Institute, Department of Hematology and Transplantology, St. 
      Petersburg, Russia.
FAU - Morozova, E
AU  - Morozova E
AD  - St. Petersburg State Medical Pavlov University, Ratsa Gorbacheva Memorial 
      Children;s Institute, Department of Hematology and Transplantology, St. 
      Petersburg, Russia.
FAU - Toren, A
AU  - Toren A
AD  - Pediatric Hemato-Oncology Unit, Sheba Medical Center (affiliated to the Sackler 
      Faculty of Medicine), Tel Hashomer, Israel.
FAU - Bielorai, B
AU  - Bielorai B
AD  - Pediatric Hemato-Oncology Unit, Sheba Medical Center (affiliated to the Sackler 
      Faculty of Medicine), Tel Hashomer, Israel.
FAU - Korsakas, J
AU  - Korsakas J
AD  - Department of Hematology, Oncology and Transfusion Medicine Center, Vilnius 
      University Hospital Santariskiu Clinics, Vilnius, Lithuania.
FAU - Fagioli, F
AU  - Fagioli F
AD  - Stem Cell Transplantation and Cellular Therapy Unit, Pediatric Onco-Hematology 
      Division, "Regina Margherita" Children's Hospital, Turin.
FAU - Caselli, D
AU  - Caselli D
AD  - Department of Oncoematologia Pediatrica, Azienda Ospedaliero-Universitaria Meyer, 
      Florence, Italy.
FAU - Ehninger, G
AU  - Ehninger G
AD  - Department of Internal Medicine I, University Hospital Carl Gustav Carus, 
      Dresden.
FAU - Gruhn, B
AU  - Gruhn B
AD  - Department of Pediatrics, University of Jena, Jena.
FAU - Dirksen, U
AU  - Dirksen U
AD  - Department of Pediatric Hematology and Oncology, University Children's Hospital, 
      Munster, Germany.
FAU - Abdel-Rahman, F
AU  - Abdel-Rahman F
AD  - The Bone Marrow and Stem Cell Transplantation Program, King Hussein Cancer 
      Center, Amman, Jordan.
FAU - Aglietta, M
AU  - Aglietta M
AD  - Department of Istituto per la Ricerca e la Cura del Cancro, Turin, Italy.
FAU - Mastrodicasa, E
AU  - Mastrodicasa E
AD  - Section of Pediatric Hematology & Oncology, University of Perugia, Perugia, 
      Italy.
FAU - Torrent, M
AU  - Torrent M
AD  - Hospital de la Santa Creu i Sant Pau, Department of Pediatrics, Barcelona, Spain.
FAU - Corradini, P
AU  - Corradini P
AD  - Department of Hematology - Bone Marrow Transplantation Unit, Istituto Nazionale 
      dei Tumori, University of Milano, Milan, Italy.
FAU - Demeocq, F
AU  - Demeocq F
AD  - Centre Hospitalier et Universitaire de Clermont-Ferrand, Service de Pediatrie B 
      et Unite Bioclinique de Therapie Cellulaire, Clermont-Ferrand, France.
FAU - Dini, G
AU  - Dini G
AD  - Department of UO Ematologia ed Oncologia Pediatrica, Istituto G Gaslini, Genova, 
      Italy.
FAU - Dreger, P
AU  - Dreger P
AD  - Department of Internal Medicine V, University of Heidelberg, Heidelberg.
FAU - Eyrich, M
AU  - Eyrich M
AD  - Children's Hospital, Department of Paediatric Stem Cell Transplantation, 
      University of Wurzburg, Wurzburg, Germany.
FAU - Gozdzik, J
AU  - Gozdzik J
AD  - Transplantation Centre, University Children's Hospital, Cracow, Poland.
FAU - Guilhot, F
AU  - Guilhot F
AD  - Department of Hematology, University Hospital, Poitiers, France.
FAU - Holler, E
AU  - Holler E
AD  - Department of Hematology and Oncology, University of Regensburg, Regensburg.
FAU - Koscielniak, E
AU  - Koscielniak E
AD  - Department of Pediatrics 5 (Oncology, Hematology, Immunology), Olga Hospital, 
      Klinikum Stuttgart, Stuttgart, Germany.
FAU - Messina, C
AU  - Messina C
AD  - Hemo/Oncology, Department of Pediatrics, Hospital-University of Padova, Padova, 
      Italy.
FAU - Nachbaur, D
AU  - Nachbaur D
AD  - University Hospital of Innsbruck, Internal Medicine V, Department of Hematology 
      and Oncology, Innsbruck, Austria.
FAU - Sabbatini, R
AU  - Sabbatini R
AD  - Department of Oncology, Haematology, and Respiratory Diseases, Policlinico di 
      Modena, Modena.
FAU - Oldani, E
AU  - Oldani E
AD  - Department of U.S.C. Ematologia, Ospedali Riuniti, Bergamo, Italy.
FAU - Ottinger, H
AU  - Ottinger H
AD  - Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, 
      Germany.
FAU - Ozsahin, H
AU  - Ozsahin H
AD  - Paediatric Oncology Unit, University of Geneva Children's Hospital, Geneva, 
      Switzerland.
FAU - Schots, R
AU  - Schots R
AD  - Division of Clinical Hematology and BMT Unit, University Hospital Brussels, 
      Brussels, Belgium.
FAU - Siena, S
AU  - Siena S
AD  - Department of S. C. Divisione Oncologia Falck and S. C. Divisione Anatomia 
      Patologica, Ospedale Niguarda Ca' Granda, Milan, Italy.
FAU - Stein, J
AU  - Stein J
AD  - Bone marrow Transplant Unit, Department of Pediatric Hematology-Oncology, 
      Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
FAU - Sufliarska, S
AU  - Sufliarska S
AD  - Bone Marrow Transplantation Unit, Department of Pediatrics, Comenius University 
      Medical School, Bratislava, Slovak Republic.
FAU - Unal, A
AU  - Unal A
AD  - Institutions Erciyes Medical School, Department of Hematology and Oncology, 
      Kapadokya BMT Center, Kayseri, Turkey.
FAU - Ussowicz, M
AU  - Ussowicz M
AD  - Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, 
      Wroclaw Medical University, Wroclaw, Poland.
FAU - Schneider, P
AU  - Schneider P
AD  - Department of Pediatric Hematology and Oncology, Hopital Charles Nicolle, Rouen, 
      France.
FAU - Woessmann, W
AU  - Woessmann W
AD  - Department of Pediatric Hematology and Oncology, University Hospital, Giessen, 
      Germany.
FAU - Jurgens, H
AU  - Jurgens H
AD  - Department of Pediatric Hematology and Oncology, University Children's Hospital, 
      Munster, Germany.
FAU - Bregni, M
AU  - Bregni M
AD  - Unit of Medical Oncology, Ospedale San Giuseppe, Milan, Italy.
FAU - Burdach, S
AU  - Burdach S
AD  - Department of Pediatrics and Wilhelm Sander Sarcoma Unit MRI, Pediatric Oncology 
      Center, Technische Universitat Munchen. Electronic address: 
      meta-eicess@lrz.tum.de.
CN  - Solid Tumor Working Party (STWP) and the Pediatric Disease Working Party (PDWP) 
      of the European Group for Blood and Marrow Transplantation (EBMT)
CN  - Asia Pacific Blood and Marrow Transplantation (APBMT)
CN  - Pediatric Registry for Stem Cell Transplantations (PRST) and the MetaEICESS Study 
      Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110118
PL  - England
TA  - Ann Oncol
JT  - Annals of oncology : official journal of the European Society for Medical 
      Oncology
JID - 9007735
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bone Neoplasms/*mortality/*therapy
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Follow-Up Studies
MH  - Graft vs Host Disease/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sarcoma, Ewing/*mortality/*therapy
MH  - *Stem Cell Transplantation
MH  - Survival Rate
MH  - Transplantation Conditioning
MH  - Transplantation, Homologous
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2011/01/20 06:00
MHDA- 2011/10/28 06:00
CRDT- 2011/01/20 06:00
PHST- 2011/01/20 06:00 [entrez]
PHST- 2011/01/20 06:00 [pubmed]
PHST- 2011/10/28 06:00 [medline]
AID - S0923-7534(19)38449-2 [pii]
AID - 10.1093/annonc/mdq703 [doi]
PST - ppublish
SO  - Ann Oncol. 2011 Jul;22(7):1614-1621. doi: 10.1093/annonc/mdq703. Epub 2011 Jan 
      18.