PMID- 21246010
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2093-2650 (Electronic)
IS  - 1976-9180 (Print)
IS  - 1976-9180 (Linking)
VI  - 34
IP  - 6
DP  - 2010 Dec
TI  - R1467H Variants of Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) are 
      Associated with Type 2 Diabetes Mellitus in Koreans.
PG  - 368-73
LID - 10.4093/kdj.2010.34.6.368 [doi]
AB  - BACKGROUND: The human Rho guanine nucleotide exchange factor 11 (ARHGEF11) 
      functions as an activator of Rho GTPases and is thought to influence insulin 
      signaling. The R1467H variant of ARHGEF11 has been reported to be associated with 
      susceptibility to type 2 diabetes mellitus (T2DM) in Western populations. 
      METHODS: We investigated the effects of the R1467H variant on susceptibility to 
      T2DM as well as related traits in a Korean population. We genotyped the R1467H 
      (rs945508) of ARHGEF11 in 689 unrelated T2DM patients and 249 non-diabetic 
      individuals and compared the clinical and biochemical characteristics according 
      to different alleles. RESULTS: The H allele was significantly more frequent in 
      T2DM cases than in controls (P = 0.037, 17.1% and 13.1%; respectively). H 
      homozygocity was associated with a higher risk of T2DM compared to those with R/R 
      or R/H genotype (odds ratio, 5.24; 95% confidence interval, 1.06 to 25.83; P = 
      0.042). The fasting plasma glucose, HbA1c, fasting insulin, HOMA2-IR and HOMA2-%beta 
      levels did not differ significantly between different genotypes. CONCLUSION: Our 
      study replicated associations of the ARHGEF11 polymorphism with increased risk of 
      T2DM in a Korean population and thus supports previous data implicating a 
      potential role of ARHGEF11 in the etiology of T2DM. Further studies revealing the 
      underlying mechanism for this association are needed.
FAU - Jin, Qing Song
AU  - Jin QS
AD  - Diabetes Clinical Research Center, Inha University Hospital, Incheon, Korea.
FAU - Kim, So Hun
AU  - Kim SH
FAU - Piao, Shan-Ji
AU  - Piao SJ
FAU - Lim, Hyun Ae
AU  - Lim HA
FAU - Lee, Seung Youn
AU  - Lee SY
FAU - Hong, Seong Bin
AU  - Hong SB
FAU - Kim, Yong Seong
AU  - Kim YS
FAU - Lee, Hun-Jae
AU  - Lee HJ
FAU - Nam, Moonsuk
AU  - Nam M
LA  - eng
PT  - Journal Article
DEP - 20101231
PL  - Korea (South)
TA  - Korean Diabetes J
JT  - Korean diabetes journal
JID - 101477168
PMC - PMC3021113
OTO - NOTNLM
OT  - Diabetes mellitus, type 2
OT  - Korean
OT  - Rho guanine nucleotide exchange factor 11
OT  - Single nucleotide polymorphism
OT  - Susceptibility gene
EDAT- 2011/01/20 06:00
MHDA- 2011/01/20 06:01
PMCR- 2010/12/01
CRDT- 2011/01/20 06:00
PHST- 2010/05/20 00:00 [received]
PHST- 2010/09/28 00:00 [accepted]
PHST- 2011/01/20 06:00 [entrez]
PHST- 2011/01/20 06:00 [pubmed]
PHST- 2011/01/20 06:01 [medline]
PHST- 2010/12/01 00:00 [pmc-release]
AID - 10.4093/kdj.2010.34.6.368 [doi]
PST - ppublish
SO  - Korean Diabetes J. 2010 Dec;34(6):368-73. doi: 10.4093/kdj.2010.34.6.368. Epub 
      2010 Dec 31.