PMID- 21247752
OWN - NLM
STAT- MEDLINE
DCOM- 20110916
LR  - 20240320
IS  - 1879-0380 (Electronic)
IS  - 0959-437X (Print)
IS  - 0959-437X (Linking)
VI  - 21
IP  - 3
DP  - 2011 Jun
TI  - Revealing the genetic basis of multiple sclerosis: are we there yet?
PG  - 317-24
LID - 10.1016/j.gde.2010.12.006 [doi]
AB  - For more than 30 years the only genetic factor associated with susceptibility to 
      multiple sclerosis (MS) was the human leukocyte antigen (HLA) region. Recent 
      advancements in genotyping platforms and the development of more effective 
      statistical methods resulted in the identification of 16 more genes by 
      genome-wide association studies (GWAS) in the last three years alone. While the 
      effect of each of these genes is modest compared to that of HLA, this list is 
      expected to grow significantly in the near future, thus defining a complex 
      landscape in which susceptibility may be determined by a combination of allelic 
      variants in different pathways according to ethnic background, disease sub-type, 
      and specific environmental triggers. A considerable overlap of susceptibility 
      genes among multiple autoimmune diseases is becoming evident and integration of 
      these genetic variants with our current knowledge of affected biological pathways 
      will greatly improve our understanding of mechanisms of general autoimmunity and 
      of tissue specificity.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Baranzini, Sergio E
AU  - Baranzini SE
AD  - Department of Neurology, School of Medicine, University of California San 
      Francisco, 513 Parnassus Ave., Room S-256, San Francisco, CA 94143-0435, United 
      States. sebaran@cgl.ucsf.edu
LA  - eng
GR  - R01 NS049477/NS/NINDS NIH HHS/United States
GR  - R01 NS049477-07/NS/NINDS NIH HHS/United States
GR  - R01NS049477/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110117
PL  - England
TA  - Curr Opin Genet Dev
JT  - Current opinion in genetics & development
JID - 9111375
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Autoimmune Diseases/genetics
MH  - Autoimmunity/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genome-Wide Association Study
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Multiple Sclerosis/*genetics
MH  - Organ Specificity/genetics
PMC - PMC3105160
MID - NIHMS261426
EDAT- 2011/01/21 06:00
MHDA- 2011/09/17 06:00
PMCR- 2012/06/01
CRDT- 2011/01/21 06:00
PHST- 2010/11/30 00:00 [received]
PHST- 2010/12/21 00:00 [accepted]
PHST- 2011/01/21 06:00 [entrez]
PHST- 2011/01/21 06:00 [pubmed]
PHST- 2011/09/17 06:00 [medline]
PHST- 2012/06/01 00:00 [pmc-release]
AID - S0959-437X(10)00201-7 [pii]
AID - 10.1016/j.gde.2010.12.006 [doi]
PST - ppublish
SO  - Curr Opin Genet Dev. 2011 Jun;21(3):317-24. doi: 10.1016/j.gde.2010.12.006. Epub 
      2011 Jan 17.