PMID- 21248041
OWN - NLM
STAT- MEDLINE
DCOM- 20110513
LR  - 20211020
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 85
IP  - 7
DP  - 2011 Apr
TI  - Vital role for CD8+ cells in controlling retroviral infections.
PG  - 3415-23
LID - 10.1128/JVI.01768-10 [doi]
AB  - Antiviral adaptive immune defenses consist of humoral and cell-mediated 
      responses, which together eliminate extracellular and intracellular virus. As 
      most retrovirus-infected individuals do not raise efficient protective antivirus 
      immune responses, the relative importance of humoral and cell-mediated responses 
      in restraining retroviral infection is not well understood. We utilized 
      retrovirus-resistant I/LnJ mice, which control infection with mouse mammary tumor 
      virus (MMTV) and murine leukemia virus (MuLV) via an adaptive immune mechanism, 
      to assess the contribution of cellular responses and virus-neutralizing 
      antibodies (Abs) to the control of retroviral infection. We found that in 
      retrovirus-infected CD8-deficient I/LnJ mice, viral titers exceed the 
      neutralizing capability of antiviral Abs, resulting in augmented virus spread and 
      disease induction. Thus, even in the presence of robust neutralizing Ab 
      responses, CD8-mediated responses are essential for full protection against 
      retroviral infection.
FAU - Kane, Melissa
AU  - Kane M
AD  - Department of Microbiology, University of Chicago, 920 E. 58th Street, Chicago, 
      IL 60637, USA.
FAU - Case, Laure K
AU  - Case LK
FAU - Golovkina, Tatyana V
AU  - Golovkina TV
LA  - eng
GR  - R01 CA089116/CA/NCI NIH HHS/United States
GR  - P30 CA014599/CA/NCI NIH HHS/United States
GR  - CA89116/CA/NCI NIH HHS/United States
GR  - R01 CA134667/CA/NCI NIH HHS/United States
GR  - CA1134667/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110119
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Animals
MH  - Antibodies, Neutralizing/immunology
MH  - Antibodies, Viral/immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Leukemia Virus, Murine/*immunology
MH  - Mammary Tumor Virus, Mouse/*immunology
MH  - Mice
MH  - Retroviridae Infections/*immunology
PMC - PMC3067886
EDAT- 2011/01/21 06:00
MHDA- 2011/05/14 06:00
PMCR- 2011/10/01
CRDT- 2011/01/21 06:00
PHST- 2011/01/21 06:00 [entrez]
PHST- 2011/01/21 06:00 [pubmed]
PHST- 2011/05/14 06:00 [medline]
PHST- 2011/10/01 00:00 [pmc-release]
AID - JVI.01768-10 [pii]
AID - 1768-10 [pii]
AID - 10.1128/JVI.01768-10 [doi]
PST - ppublish
SO  - J Virol. 2011 Apr;85(7):3415-23. doi: 10.1128/JVI.01768-10. Epub 2011 Jan 19.