PMID- 21248056
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20211020
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 203
IP  - 4
DP  - 2011 Feb 15
TI  - Follow-up survey of children who received sulfadoxine-pyrimethamine for 
      intermittent preventive antimalarial treatment in infants.
PG  - 556-60
LID - 10.1093/infdis/jiq079 [doi]
AB  - Recently, the World Health Organization emphasized the potential benefit of 
      intermittent preventive treatment in infants (IPTi) to control malaria and 
      officially recommended implementation of IPTi with sulfadoxine-pyrimethamine (SP) 
      in areas with moderate and high transmission, where SP resistance is not high. As 
      reported rebound effects make further observation mandatory, we performed a 
      survey of participants of a former IPTi trial. Malariometric parameters were 
      similar in the SP and the placebo group. In contrast, anti-Plasmodium falciparum 
      lysate immunoglobulin G antibody levels, a proxy measure for preceding malaria 
      episodes, remained lower in the SP arm. The most likely explanation is a lower 
      overall exposure to parasitic antigens after IPTi.
FAU - Kobbe, Robin
AU  - Kobbe R
AD  - Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, 
      Hamburg, Germany. kobbe@bni-hamburg.de
FAU - Hogan, Benedikt
AU  - Hogan B
FAU - Adjei, Samuel
AU  - Adjei S
FAU - Klein, Philipp
AU  - Klein P
FAU - Kreuels, Benno
AU  - Kreuels B
FAU - Loag, Wibke
AU  - Loag W
FAU - Adjei, Ohene
AU  - Adjei O
FAU - May, Jurgen
AU  - May J
LA  - eng
PT  - Journal Article
DEP - 20101220
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (Antimalarials)
RN  - 0 (Drug Combinations)
RN  - 0 (Immunoglobulin G)
RN  - 37338-39-9 (fanasil, pyrimethamine drug combination)
RN  - 88463U4SM5 (Sulfadoxine)
RN  - Z3614QOX8W (Pyrimethamine)
SB  - IM
MH  - Antibodies, Protozoan/blood
MH  - Antimalarials/*therapeutic use
MH  - Chemoprevention/*methods
MH  - Child, Preschool
MH  - Drug Combinations
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Infant
MH  - Malaria, Falciparum/*epidemiology/*prevention & control
MH  - Male
MH  - Plasmodium falciparum/immunology
MH  - Pyrimethamine/*therapeutic use
MH  - Seroepidemiologic Studies
MH  - Sulfadoxine/*therapeutic use
PMC - PMC3071230
EDAT- 2011/01/21 06:00
MHDA- 2011/02/25 06:00
PMCR- 2010/12/20
CRDT- 2011/01/21 06:00
PHST- 2011/01/21 06:00 [entrez]
PHST- 2011/01/21 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
PHST- 2010/12/20 00:00 [pmc-release]
AID - jiq079 [pii]
AID - 10.1093/infdis/jiq079 [doi]
PST - ppublish
SO  - J Infect Dis. 2011 Feb 15;203(4):556-60. doi: 10.1093/infdis/jiq079. Epub 2010 
      Dec 20.