PMID- 21248776
OWN - NLM
STAT- MEDLINE
DCOM- 20111004
LR  - 20211020
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 12
IP  - 3
DP  - 2011 Apr
TI  - CIITA is not associated with risk of developing rheumatoid arthritis.
PG  - 235-8
LID - 10.1038/gene.2010.67 [doi]
AB  - The major histocompatibility complex (MHC) class II transactivator gene (CIITA) 
      encodes an important transcription factor regulating genes required for human 
      leukocyte antigen (HLA) class II MHC-restricted antigen presentation. MHC genes, 
      particularly HLA class II, are strongly associated with risk of developing 
      rheumatoid arthritis (RA). Given the strong biological relationship between CIITA 
      and HLA class II genes, a comprehensive investigation of CIITA variation in RA 
      was conducted. This study tested 31 CIITA single-nucleotide polymorphisms in 2542 
      RA cases and 3690 controls (N=6232). All individuals were of European ancestry, 
      as determined by ancestry informative genetic markers. No evidence for 
      association between CIITA variation and RA was observed after a correction for 
      multiple testing was applied. This is the largest study to fully characterize 
      common genetic variation in CIITA, including an assessment of haplotypes. Results 
      exclude even a modest role for common CIITA polymorphisms in susceptibility to 
      RA.
FAU - Bronson, P G
AU  - Bronson PG
AD  - Division of Epidemiology, Genetic Epidemiology and Genomics Laboratory, School of 
      Public Health, University of California, Berkeley, CA 94720-7356, USA.
FAU - Ramsay, P P
AU  - Ramsay PP
FAU - Seldin, M F
AU  - Seldin MF
FAU - Gregersen, P K
AU  - Gregersen PK
FAU - Criswell, L A
AU  - Criswell LA
FAU - Barcellos, L F
AU  - Barcellos LF
LA  - eng
GR  - 5 M01 RR-00079/RR/NCRR NIH HHS/United States
GR  - R01 AR044422/AR/NIAMS NIH HHS/United States
GR  - K24 AR02175/AR/NIAMS NIH HHS/United States
GR  - R01 AR44422/AR/NIAMS NIH HHS/United States
GR  - K24 AR002175/AR/NIAMS NIH HHS/United States
GR  - N01 AR22263/AR/NIAMS NIH HHS/United States
GR  - N01AR22263/AR/NIAMS NIH HHS/United States
GR  - F31 AI075609/AI/NIAID NIH HHS/United States
GR  - M01 RR000079/RR/NCRR NIH HHS/United States
GR  - R01 AI059829/AI/NIAID NIH HHS/United States
GR  - R01 AR050267/AR/NIAMS NIH HHS/United States
GR  - R01 AI065841/AI/NIAID NIH HHS/United States
GR  - 076113/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110120
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (MHC class II transactivator protein)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Trans-Activators)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Arthritis, Rheumatoid/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nuclear Proteins/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/genetics
MH  - Trans-Activators/*genetics
MH  - Young Adult
PMC - PMC3449225
MID - NIHMS403907
EDAT- 2011/01/21 06:00
MHDA- 2011/10/05 06:00
PMCR- 2012/09/24
CRDT- 2011/01/21 06:00
PHST- 2011/01/21 06:00 [entrez]
PHST- 2011/01/21 06:00 [pubmed]
PHST- 2011/10/05 06:00 [medline]
PHST- 2012/09/24 00:00 [pmc-release]
AID - gene201067 [pii]
AID - 10.1038/gene.2010.67 [doi]
PST - ppublish
SO  - Genes Immun. 2011 Apr;12(3):235-8. doi: 10.1038/gene.2010.67. Epub 2011 Jan 20.