PMID- 21251304
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220330
IS  - 1743-7075 (Electronic)
IS  - 1743-7075 (Linking)
VI  - 8
DP  - 2011 Jan 20
TI  - Circulating interleukin-18: A specific biomarker for atherosclerosis-prone 
      patients with metabolic syndrome.
PG  - 3
LID - 10.1186/1743-7075-8-3 [doi]
AB  - BACKGROUND: Metabolic syndrome (MetS) is associated with an increased risk of the 
      development of atherosclerotic cardiovascular disease (CVD). Interleukin-18 
      (IL-18), which is a pleiotropic proinflammatory cytokine with important 
      regulatory functions in the innate immune response system, plays a crucial role 
      in vascular pathologies. IL-18 is also a predictor of cardiovascular death in 
      patients with CVD and is involved in atherosclerotic plaque destabilization. 
      RESULTS: In order to determine if circulating levels of IL-18 can serve as a 
      specific biomarker for distinguishing MetS patients from pre-MetS subjects, we 
      studied 78 patients with visceral fat deposition and 14 age-matched control 
      subjects. Increased levels of IL-18 were observed more frequently in patients 
      with MetS than in pre-MetS subjects and were positively associated with waist 
      circumference. Serum levels of IL-18 were significantly reduced by a change in 
      weight caused by lifestyle modifications. There was a significant interaction 
      between waist circumference and serum IL-18 concentration. Weight loss of at 
      least 5% of the body weight caused by lifestyle modification decreased IL-18 
      circulating levels relative to the reduction in waist circumference and blood 
      pressure, suggesting that this degree of weight loss benefits the cardiovascular 
      system. CONCLUSION: IL-18 may be a useful biomarker of the clinical 
      manifestations of MetS and for the management of the risk factors of CVD.
FAU - Yamaoka-Tojo, Minako
AU  - Yamaoka-Tojo M
AD  - Department of Rehabilitation, Kitasato University School of Allied Health 
      Sciences, 1-15-1 Kitasato, Minami-ku, Sagamihara, 252-0373 Kanagawa, Japan. 
      myamaoka@med.kitasato-u.ac.jp.
FAU - Tojo, Taiki
AU  - Tojo T
FAU - Wakaume, Kazuki
AU  - Wakaume K
FAU - Kameda, Ryo
AU  - Kameda R
FAU - Nemoto, Shinji
AU  - Nemoto S
FAU - Takahira, Naonobu
AU  - Takahira N
FAU - Masuda, Takashi
AU  - Masuda T
FAU - Izumi, Tohru
AU  - Izumi T
LA  - eng
PT  - Journal Article
DEP - 20110120
PL  - England
TA  - Nutr Metab (Lond)
JT  - Nutrition & metabolism
JID - 101231644
PMC - PMC3038890
EDAT- 2011/01/22 06:00
MHDA- 2011/01/22 06:01
PMCR- 2011/01/20
CRDT- 2011/01/22 06:00
PHST- 2010/11/14 00:00 [received]
PHST- 2011/01/20 00:00 [accepted]
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/01/22 06:01 [medline]
PHST- 2011/01/20 00:00 [pmc-release]
AID - 1743-7075-8-3 [pii]
AID - 10.1186/1743-7075-8-3 [doi]
PST - epublish
SO  - Nutr Metab (Lond). 2011 Jan 20;8:3. doi: 10.1186/1743-7075-8-3.