PMID- 21252243
OWN - NLM
STAT- MEDLINE
DCOM- 20110614
LR  - 20220331
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 96
IP  - 4
DP  - 2011 Apr
TI  - Interrelationship between fatty liver and insulin resistance in the development 
      of type 2 diabetes.
PG  - 1093-7
LID - 10.1210/jc.2010-2190 [doi]
AB  - CONTEXT: Although fatty liver and insulin resistance are known to be associated, 
      the relationship between the two in the development of type 2 diabetes mellitus 
      (T2DM) is unclear. OBJECTIVE: We investigated the 5-yr risk of developing T2DM in 
      individuals diagnosed with fatty liver using ultrasound and stratified by insulin 
      sensitivity using quartiles of fasting insulin concentration. DESIGN AND METHODS: 
      We examined the clinical and laboratory data of 11,091 Koreans who had a medical 
      evaluation including fasting insulin concentration and abdominal ultrasound at 
      baseline and had a follow-up after 5 yr. RESULTS: At baseline, 27% of the 
      population had fatty liver. Almost half (47%) of the individuals with fatty liver 
      had baseline insulin concentration in the highest quartile compared with 17% in 
      those without fatty liver (P < 0.001). Regardless of baseline insulin 
      concentration, individuals with fatty liver had significantly (P < 0.001) more 
      baseline clinical and metabolic abnormalities, including higher glucose and 
      triglyceride concentration and lower high-density lipoprotein cholesterol 
      concentration. In addition, regardless of baseline insulin concentration, 
      individuals with fatty liver had a significantly increased risk for incident T2DM 
      compared with those without fatty liver [crude odds ratio, 5.05 (95% confidence 
      interval, 2.08-12.29) in the lowest insulin quartile and 6.34 (3.58-11.21) in the 
      highest quartile]. In individuals in the highest insulin quartile, the odds ratio 
      for developing T2DM remained significant even after multivariate adjustment 
      including baseline glucose concentration [2.42 (1.23-4.75)]. CONCLUSION: Although 
      associated with insulin resistance, fatty liver diagnosed by ultrasound appears 
      to independently increase the risk of T2DM.
FAU - Sung, Ki-Chul
AU  - Sung KC
AD  - Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, 
      Sungkyunkwan University, Seoul, South Korea. kcmd.sung@samsung.com
FAU - Kim, Sun H
AU  - Kim SH
LA  - eng
GR  - K23 MH079114/MH/NIMH NIH HHS/United States
GR  - K23MH079114/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110120
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/diagnosis/epidemiology/*etiology
MH  - Fatty Liver/*complications/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance/*physiology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Risk Factors
PMC - PMC3070249
EDAT- 2011/01/22 06:00
MHDA- 2011/06/15 06:00
PMCR- 2012/04/01
CRDT- 2011/01/22 06:00
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/06/15 06:00 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - jc.2010-2190 [pii]
AID - 10-2190 [pii]
AID - 10.1210/jc.2010-2190 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2011 Apr;96(4):1093-7. doi: 10.1210/jc.2010-2190. Epub 
      2011 Jan 20.