PMID- 21253407
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1976-3026 (Electronic)
IS  - 1738-3684 (Print)
IS  - 1738-3684 (Linking)
VI  - 7
IP  - 4
DP  - 2010 Dec
TI  - The role of BDNF as a mediator of neuroplasticity in bipolar disorder.
PG  - 243-50
LID - 10.4306/pi.2010.7.4.243 [doi]
AB  - The cognitive impairment and neuroanatomical changes that takes place among 
      patients with bipolar disorder (BD) patients has been well described. Recent data 
      suggest that changes in neuroplasticity, cell resilience and connectivity are the 
      main neuropathological findings in BD. Data from differential lines of research 
      converges to the brain-derived neurotrophic factor (BDNF) as an important 
      contributor to the neuroplasticity changes described among BD patients. BDNF 
      serum levels have been shown to be decreased in depressive and manic episodes, 
      returning to normal levels in euthymia. BDNF has also been shown to decrease as 
      the disorder progresses. Moreover, factors that negatively influence the course 
      of BD, such as life stress and trauma have been shown to be associated with a 
      decrease in BDNF serum levels. These findings suggest that BDNF plays a central 
      role in the progression of BD. The present review discusses the role of BDNF as a 
      mediator of the neuroplastic changes that occur in portion with mood episodes and 
      the potential use of serum BDNF as a biomarker in BD.
FAU - Grande, Iria
AU  - Grande I
AD  - Bipolar Disorder Program and Laboratory of Molecular Psychiatry, Hospital de 
      Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, 
      Brazil.
FAU - Fries, Gabriel Rodrigo
AU  - Fries GR
FAU - Kunz, Mauricio
AU  - Kunz M
FAU - Kapczinski, Flavio
AU  - Kapczinski F
LA  - eng
PT  - Journal Article
DEP - 20101215
PL  - Korea (South)
TA  - Psychiatry Investig
JT  - Psychiatry investigation
JID - 101242994
PMC - PMC3022310
OTO - NOTNLM
OT  - Bipolar disorder
OT  - Brain-derived neurotrophic factor
OT  - Neuroplasticity
OT  - Neurotrophins
OT  - Stress
EDAT- 2011/01/22 06:00
MHDA- 2011/01/22 06:01
PMCR- 2010/12/01
CRDT- 2011/01/22 06:00
PHST- 2010/07/26 00:00 [received]
PHST- 2010/09/07 00:00 [accepted]
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/01/22 06:01 [medline]
PHST- 2010/12/01 00:00 [pmc-release]
AID - 10.4306/pi.2010.7.4.243 [doi]
PST - ppublish
SO  - Psychiatry Investig. 2010 Dec;7(4):243-50. doi: 10.4306/pi.2010.7.4.243. Epub 
      2010 Dec 15.