PMID- 21253413
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1976-3026 (Electronic)
IS  - 1738-3684 (Print)
IS  - 1738-3684 (Linking)
VI  - 7
IP  - 4
DP  - 2010 Dec
TI  - Gender-specific association of the brain-derived neurotrophic factor gene with 
      attention-deficit/hyperactivity disorder.
PG  - 285-90
LID - 10.4306/pi.2010.7.4.285 [doi]
AB  - OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) is a complex 
      neurodevelopmental disorder with a strong genetic component. Brain-derived 
      neurotrophic factor (BDNF), which participates in the differentiation and 
      survival of dopaminergic and noradrenergic neurons, could play a role in ADHD 
      development. We aimed to explore the relationships between ADHD and BDNF gene 
      polymorphism. METHODS: We conducted a case-control analysis of 202 ADHD subjects 
      and 159 controls, performed a transmission disequilibrium test on 151 trios, and 
      compared the results of a continuous performance test (CPT) according to the 
      genotype of the three single nucleotide polymorphisms (rs11030101, rs6265, 
      rs16917204) in the BDNF gene. RESULTS: In the case-control analysis, the AA 
      genotype of the BDNF rs11030101 polymorphism was significantly associated with 
      ADHD only in girls (p=0.024, odds ratio=3.00). The T-G-G haplotype was 
      significantly less frequent (p=0.005) and A-G-G was more frequent (p=0.048) in 
      girls with ADHD than in control girls (global p=0.027). A multivariate analysis 
      of variance for commission errors on the CPT showed a significant main effect for 
      the rs11030101 genotype (p=0.026) and an interaction effect of the rs11030101 
      genotype and gender (p=0.032) in ADHD probands. CONCLUSION: These results provide 
      preliminary evidence for a gender-specific association between BDNF and ADHD in 
      the Korean population.
FAU - Cho, Soo-Churl
AU  - Cho SC
AD  - Department of Child and Adolescent Psychiatry, Seoul National University College 
      of Medicine, Seoul, Korea.
FAU - Kim, Hyo-Won
AU  - Kim HW
FAU - Kim, Boong-Nyun
AU  - Kim BN
FAU - Kim, Jae-Won
AU  - Kim JW
FAU - Shin, Min-Sup
AU  - Shin MS
FAU - Chung, Seockhoon
AU  - Chung S
FAU - Cho, Dae-Yeon
AU  - Cho DY
FAU - Jung, Sun-Woo
AU  - Jung SW
FAU - Yoo, Hee Jeong
AU  - Yoo HJ
FAU - Chung, In-Won
AU  - Chung IW
FAU - Chung, Un-Sun
AU  - Chung US
FAU - Son, Jung-Woo
AU  - Son JW
LA  - eng
PT  - Journal Article
DEP - 20101123
PL  - Korea (South)
TA  - Psychiatry Investig
JT  - Psychiatry investigation
JID - 101242994
PMC - PMC3022316
OTO - NOTNLM
OT  - Association studies
OT  - Attention-deficit/hyperactivity disorder
OT  - Brain-derived neurotrophic factor
OT  - Continuous performance test
OT  - Single nucleotide polymorphism
EDAT- 2011/01/22 06:00
MHDA- 2011/01/22 06:01
PMCR- 2010/12/01
CRDT- 2011/01/22 06:00
PHST- 2010/05/10 00:00 [received]
PHST- 2010/08/31 00:00 [revised]
PHST- 2010/09/15 00:00 [accepted]
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/01/22 06:01 [medline]
PHST- 2010/12/01 00:00 [pmc-release]
AID - 10.4306/pi.2010.7.4.285 [doi]
PST - ppublish
SO  - Psychiatry Investig. 2010 Dec;7(4):285-90. doi: 10.4306/pi.2010.7.4.285. Epub 
      2010 Nov 23.