PMID- 21254083
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20151119
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 43
IP  - 2
DP  - 2011 Feb
TI  - Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral 
      sclerosis: clinical and biological results from a prospective multicenter study.
PG  - 189-95
LID - 10.1002/mus.21851 [doi]
AB  - Granulocyte colony-stimulating factor (G-CSF) induces a transient mobilization of 
      hematopoietic progenitor cells from bone marrow to peripheral blood. Our aim was 
      to evaluate safety of repeated courses of G-CSF in patients with amyotrophic 
      lateral sclerosis (ALS), assessing disease progression and changes in chemokine 
      and cytokine levels in serum and cerebrospinal fluid (CSF). Twenty-four ALS 
      patients entered an open-label, multicenter trial in which four courses of G-CSF 
      and mannitol were administered at 3-month intervals. Levels of G-CSF were 
      increased after treatment in the serum and CSF. Few and transitory adverse events 
      were observed. No significant reduction of the mean monthly decrease in ALSFRS-R 
      score and forced vital capacity was observed. A significant reduction in CSF 
      levels of monocyte chemoattractant protein-1 (MCP-1) and interleukin-17 (IL-17) 
      was observed. G-CSF treatment was safe and feasible in a multicenter series of 
      ALS patients. A decrease in the CSF levels of proinflammatory cytokines MCP-1 and 
      IL-17 was found, indicating a G-CSF-induced central anti-inflammatory response.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Chio, Adriano
AU  - Chio A
AD  - Dipartimento di Neuroscienze, Centro per la Sclerosi Laterale Amiotrofica, 
      Torino, Italy. achio@usa.net
FAU - Mora, Gabriele
AU  - Mora G
FAU - La Bella, Vincenzo
AU  - La Bella V
FAU - Caponnetto, Claudia
AU  - Caponnetto C
FAU - Mancardi, Gianluigi
AU  - Mancardi G
FAU - Sabatelli, Mario
AU  - Sabatelli M
FAU - Siciliano, Gabriele
AU  - Siciliano G
FAU - Silani, Vincenzo
AU  - Silani V
FAU - Corbo, Massimo
AU  - Corbo M
FAU - Moglia, Cristina
AU  - Moglia C
FAU - Calvo, Andrea
AU  - Calvo A
FAU - Mutani, Roberto
AU  - Mutani R
FAU - Rutella, Sergio
AU  - Rutella S
FAU - Gualandi, Francesca
AU  - Gualandi F
FAU - Melazzini, Mario
AU  - Melazzini M
FAU - Scime, Rosanna
AU  - Scime R
FAU - Petrini, Mario
AU  - Petrini M
FAU - Bondesan, Paola
AU  - Bondesan P
FAU - Garbelli, Silvia
AU  - Garbelli S
FAU - Mantovani, Stefania
AU  - Mantovani S
FAU - Bendotti, Caterina
AU  - Bendotti C
FAU - Tarella, Corrado
AU  - Tarella C
CN  - STEMALS Study Group
LA  - eng
PT  - Clinical Trial, Phase I
PT  - Clinical Trial, Phase II
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (Cytokines)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
SB  - IM
CIN - Muscle Nerve. 2011 Jul;44(1):149; author reply 149-50. PMID: 21674531
MH  - Adult
MH  - Aged
MH  - Amyotrophic Lateral Sclerosis/blood/cerebrospinal fluid/*drug therapy
MH  - Cytokines/blood/cerebrospinal fluid
MH  - Disability Evaluation
MH  - Female
MH  - Follow-Up Studies
MH  - Granulocyte Colony-Stimulating Factor/blood/cerebrospinal fluid/*therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
FIR - Ghiglione, Paolo
IR  - Ghiglione P
FIR - Omede, Paola
IR  - Omede P
FIR - Ulla, Marco
IR  - Ulla M
FIR - Mascolo, Maria
IR  - Mascolo M
FIR - Carlesi, Cecilia
IR  - Carlesi C
FIR - Tonali, Pietro Attilio
IR  - Tonali PA
FIR - Conte, Amelia
IR  - Conte A
FIR - Luigetti, Marco
IR  - Luigetti M
FIR - Alimonti, Dario
IR  - Alimonti D
FIR - Onida, Francesco
IR  - Onida F
FIR - Bossolasco, Patrizia
IR  - Bossolasco P
FIR - Lambertenghi Deliliers, Giorgio
IR  - Lambertenghi Deliliers G
FIR - Valentino, Francesca
IR  - Valentino F
EDAT- 2011/01/22 06:00
MHDA- 2011/02/25 06:00
CRDT- 2011/01/22 06:00
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - 10.1002/mus.21851 [doi]
PST - ppublish
SO  - Muscle Nerve. 2011 Feb;43(2):189-95. doi: 10.1002/mus.21851.