PMID- 21254154
OWN - NLM
STAT- MEDLINE
DCOM- 20110224
LR  - 20131121
IS  - 1097-0045 (Electronic)
IS  - 0270-4137 (Linking)
VI  - 71
IP  - 4
DP  - 2011 Mar 1
TI  - Effect of a phytotherapeutic agent, Eviprostat(R), on prostatic and urinary 
      cytokines/chemokines in a rat model of nonbacterial prostatitis.
PG  - 438-44
LID - 10.1002/pros.21299 [doi]
AB  - BACKGROUND: Chronic inflammation in the prostate has recently been recognized as 
      an important component of the symptom progression of benign prostatic 
      hyperplasia. The objective of this study was to evaluate a range of 
      cytokines/chemokines in prostate tissue and urine to identify markers of prostate 
      inflammation in a prostatitis model and to investigate the effect of a 
      phytotherapeutic agent, Eviprostat(R), on these markers. METHODS: Ten-month-old 
      male Wistar rats were divided into four groups. Nonbacterial prostatitis (NBP) 
      was experimentally induced in groups 2-4 by castration followed by daily 
      subcutaneous injection of 17beta-estradiol for 30 days. Control rats were fed a 
      standard diet, while animals in the Eviprostat groups were fed a diet containing 
      0.05 or 0.1% Eviprostat for 30 days. The levels of cytokines/chemokines in 
      prostate tissue on the 31st day and in urine collected the day before castration 
      and the day before removal of the prostate were determined. RESULTS: 
      Experimentally induced NBP increased the prostatic levels of the cytokines 
      interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha). The levels of the 
      chemokines CCL2/monocyte chemoattractant protein-1 (MCP-1), CCL3/macrophage 
      inflammatory protein-1alpha (MIP-1alpha), CXCL1/CINC-1, CXCL3/CINC-2, and CXCL5/LIX were 
      elevated in both prostate and urine. Eviprostat significantly suppressed the 
      increases in prostate IL-1beta, TNF-alpha and CCL3/MIP-1alpha and prostatic and urinary 
      CCL2/MCP-1 and CXCL1/CINC-1. CONCLUSIONS: Chemokines, including CCL2/MCP-1 and 
      CXCL1/CINC-1, were elevated in the prostate and urine of NBP rats, and Eviprostat 
      potently suppressed the increases in CCL2/MCP-1 and CXCL1/CINC-1. These 
      chemokines are therefore candidate diagnostic biomarkers for nonbacterial chronic 
      prostatic inflammation.
CI  - Copyright (c) 2010 Wiley-Liss, Inc.
FAU - Sugimoto, Mikio
AU  - Sugimoto M
AD  - Department of Urology, Kagawa University Faculty of Medicine, Kita-gun, Kagawa, 
      Japan. micsugi@med.kagawa-u.ac.jp
FAU - Oka, Michiko
AU  - Oka M
FAU - Tsunemori, Hiroyuki
AU  - Tsunemori H
FAU - Yamashita, Motoki
AU  - Yamashita M
FAU - Kakehi, Yoshiyuki
AU  - Kakehi Y
LA  - eng
PT  - Journal Article
DEP - 20101028
PL  - United States
TA  - Prostate
JT  - The Prostate
JID - 8101368
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Drug Combinations)
RN  - 0 (Plant Extracts)
RN  - 24YL531VOH (Ethamsylate)
RN  - 59738-67-9 (eviprostat)
SB  - IM
MH  - Animals
MH  - Chemokines/*analysis/urine
MH  - Cytokines/*analysis/urine
MH  - Drug Combinations
MH  - Ethamsylate/pharmacology/*therapeutic use
MH  - Male
MH  - *Phytotherapy
MH  - Plant Extracts/pharmacology/*therapeutic use
MH  - Prostate/*immunology
MH  - Prostatic Hyperplasia/*drug therapy
MH  - Prostatitis/drug therapy/*immunology
MH  - Rats
MH  - Rats, Wistar
EDAT- 2011/01/22 06:00
MHDA- 2011/02/25 06:00
CRDT- 2011/01/22 06:00
PHST- 2010/08/06 00:00 [received]
PHST- 2010/09/26 00:00 [accepted]
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2011/02/25 06:00 [medline]
AID - 10.1002/pros.21299 [doi]
PST - ppublish
SO  - Prostate. 2011 Mar 1;71(4):438-44. doi: 10.1002/pros.21299. Epub 2010 Oct 28.