PMID- 21254295
OWN - NLM
STAT- MEDLINE
DCOM- 20120126
LR  - 20220311
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 33
IP  - 10
DP  - 2011 Oct
TI  - CCND1 amplification and protein overexpression in oral squamous cell carcinoma of 
      young patients.
PG  - 1413-9
LID - 10.1002/hed.21618 [doi]
AB  - BACKGROUND: The purpose of this study was to evaluate the correlation of CCND1 
      amplification and protein overexpression with clinicopathological features and 
      clinical outcomes in patients younger than 41 years old with oral squamous cell 
      carcinoma (SCC). METHODS: Eighty-six young patients with oral SCC were evaluated 
      using the tissue microarray technique, immunohistochemistry, and fluorescence in 
      situ hybridization (FISH). These cases were compared with 116 patients with oral 
      cancer aged over 50 years old (controls). RESULTS: Cyclin D1 overexpression was 
      observed in 47.7% of tumors in the young group and in 32.8% of controls (p = 
      .03). In the young group, CCND1 amplification and overexpression were higher than 
      in the control patients and the differences were statistically significant. In 
      the young group, protein overexpression correlated with diminished disease-free 
      survival (DFS), whereas in the control patients, cyclin D1 overexpression 
      correlated with diminished DFS and overall survival (OS). CONCLUSION: In both 
      groups, amplification had no influence on prognosis. Protein overexpression was 
      an indicator of worse DFS in both groups.
CI  - Copyright (c) 2011 Wiley Periodicals, Inc.
FAU - Kaminagakura, Estela
AU  - Kaminagakura E
AD  - Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo 
      Hospital, Sao Paulo, SP, Brazil.
FAU - Werneck da Cunha, Isabela
AU  - Werneck da Cunha I
FAU - Soares, Fernando Augusto
AU  - Soares FA
FAU - Nishimoto, Ines Nobuko
AU  - Nishimoto IN
FAU - Kowalski, Luiz Paulo
AU  - Kowalski LP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110120
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
RN  - 0 (CCND1 protein, human)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*genetics/mortality
MH  - Case-Control Studies
MH  - Cyclin D1/*genetics
MH  - Disease-Free Survival
MH  - Female
MH  - *Gene Amplification
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*genetics/mortality
MH  - Oligonucleotide Array Sequence Analysis
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2011/01/22 06:00
MHDA- 2012/01/27 06:00
CRDT- 2011/01/22 06:00
PHST- 2010/03/24 00:00 [received]
PHST- 2010/07/22 00:00 [revised]
PHST- 2010/08/12 00:00 [accepted]
PHST- 2011/01/22 06:00 [entrez]
PHST- 2011/01/22 06:00 [pubmed]
PHST- 2012/01/27 06:00 [medline]
AID - 10.1002/hed.21618 [doi]
PST - ppublish
SO  - Head Neck. 2011 Oct;33(10):1413-9. doi: 10.1002/hed.21618. Epub 2011 Jan 20.