PMID- 21256182
OWN - NLM
STAT- MEDLINE
DCOM- 20110620
LR  - 20181201
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 335
IP  - 2
DP  - 2011 Mar 30
TI  - Regulation of Sertoli cell activin A and inhibin B by tumour necrosis factor alpha 
      and interleukin 1alpha: interaction with follicle-stimulating hormone/adenosine 
      3',5'-cyclic phosphate signalling.
PG  - 195-203
LID - 10.1016/j.mce.2011.01.014 [doi]
AB  - Regulation of crucial events during spermatogenesis involves dynamic changes in 
      cytokine production and interactions across the cycle of the seminiferous 
      epithelium. Regulation of activin A and inhibin B production by the inflammatory 
      cytokines, tumour necrosis factor alpha (TNFalpha) and interleukin 1alpha (IL1alpha), alone and 
      in conjunction with FSH or a cAMP analogue (dibutyryl cAMP), was examined in 
      cultures of Sertoli cells from 20-day old rats. Both TNFalpha and IL1alpha stimulated 
      activin A secretion and expression of its subunit (beta(A)) mRNA, and suppressed 
      inhibin B secretion and expression of its subunit (alpha and beta(B)) mRNAs. The actions 
      of TNFalpha and IL1alpha were opposed by FSH and dibutyryl cAMP. Both cytokines inhibited 
      FSH/dibutyryl cAMP-stimulated inhibin B secretion and mRNA expression as well as 
      stem cell factor mRNA expression. Both cytokines also inhibited FSH-induced cAMP 
      production, and reduced baseline FSH receptor mRNA expression. These data 
      highlight the reciprocal relationship that exists between FSH/cAMP signalling and 
      inflammatory cytokine signalling pathways in the control of Sertoli cell 
      function, and production of activin A/inhibin B in particular. It is anticipated 
      that these interactions play important roles in the fine control of events during 
      the cycle of the seminiferous epithelium and in the inhibition of spermatogenesis 
      during inflammation.
CI  - Crown Copyright (c) 2011. Published by Elsevier Ireland Ltd. All rights reserved.
FAU - Kazutaka, Saito
AU  - Kazutaka S
AD  - Centre for Reproduction and Development, Monash Institute of Medical Research, 
      Monash University, Melbourne, Victoria, Australia.
FAU - Winnall, Wendy R
AU  - Winnall WR
FAU - Muir, Julie A
AU  - Muir JA
FAU - Hedger, Mark P
AU  - Hedger MP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110120
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Interleukin-1alpha)
RN  - 0 (N-acetylsphingosine)
RN  - 0 (Phosphodiesterase Inhibitors)
RN  - 0 (Protein Subunits)
RN  - 0 (Receptors, FSH)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Stem Cell Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (inhibin B)
RN  - 0 (inhibin beta A subunit)
RN  - 57285-09-3 (Inhibins)
RN  - 63X7MBT2LQ (Bucladesine)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
RN  - 93443-12-0 (Inhibin-beta Subunits)
RN  - E0399OZS9N (Cyclic AMP)
RN  - NGZ37HRE42 (Sphingosine)
SB  - IM
MH  - Animals
MH  - Bucladesine/pharmacology
MH  - Cells, Cultured
MH  - Cyclic AMP/antagonists & inhibitors/*metabolism
MH  - Down-Regulation
MH  - Follicle Stimulating Hormone/*pharmacology/physiology
MH  - Inhibin-beta Subunits/genetics/*metabolism
MH  - Inhibins/genetics/*metabolism
MH  - Interleukin-1alpha/*pharmacology/physiology
MH  - Male
MH  - Phosphodiesterase Inhibitors/pharmacology
MH  - Protein Subunits/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, FSH/genetics
MH  - Recombinant Proteins/pharmacology
MH  - Sertoli Cells
MH  - Signal Transduction
MH  - Sphingosine/analogs & derivatives/pharmacology
MH  - Stem Cell Factor/genetics
MH  - Transcription, Genetic
MH  - Tumor Necrosis Factor-alpha/*pharmacology/physiology
MH  - Up-Regulation
EDAT- 2011/01/25 06:00
MHDA- 2011/06/21 06:00
CRDT- 2011/01/25 06:00
PHST- 2010/10/14 00:00 [received]
PHST- 2011/01/13 00:00 [revised]
PHST- 2011/01/14 00:00 [accepted]
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/06/21 06:00 [medline]
AID - S0303-7207(11)00036-0 [pii]
AID - 10.1016/j.mce.2011.01.014 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2011 Mar 30;335(2):195-203. doi: 10.1016/j.mce.2011.01.014. 
      Epub 2011 Jan 20.