PMID- 21256475
OWN - NLM
STAT- MEDLINE
DCOM- 20110705
LR  - 20220318
IS  - 1873-622X (Electronic)
IS  - 0005-7967 (Print)
IS  - 0005-7967 (Linking)
VI  - 49
IP  - 3
DP  - 2011 Mar
TI  - Behavioral interventions may prolong remission in patients with inflammatory 
      bowel disease.
PG  - 145-50
LID - 10.1016/j.brat.2010.12.005 [doi]
AB  - Inflammatory Bowel Diseases (IBDs) are chronic, relapsing and remitting 
      gastrointestinal conditions with no known cure. Previous studies have linked 
      behavioral factors, including stress and medication adherence, to relapse. 
      PURPOSE: We sought to determine the effect of participation in a behavioral 
      self-management program on incidence of flare within 12 months following 
      behavioral intervention when compared to the natural history of flare incidence 
      prior to program participation. RESULTS: Results from a 2-level regression model 
      indicated that those participants in the treatment group were 57% less likely to 
      flare in the following 12 months (compared to 18% in the control group). The 
      decline in "flare odds" was about 2 times greater in treatment versus controls 
      (OR=0.52, t(34)=2.07, p<0.05). Office visits, ER visits, and disease severity 
      (all p<0.05) were identified as moderators of flare risk. CONCLUSIONS: We have 
      demonstrated 1) a statistical model estimating the likelihood of flare rates in 
      the 12 months following a behavioral intervention for IBD (compared to a control 
      condition), and 2) that the introduction of a behavioral intervention can alter 
      the natural course of a chronic, relapsing and remitting gastrointestinal 
      condition such as IBD.
CI  - Copyright (c) 2010 Elsevier Ltd. All rights reserved.
FAU - Keefer, Laurie
AU  - Keefer L
AD  - Division of Gastroenterology, Northwestern University Feinberg School of 
      Medicine, Center for Psychosocial Research, 676N. St. Clair, Suite 1400, Chicago, 
      IL 60611, USA. laurie.keefer@northwestern.edu
FAU - Kiebles, Jennifer L
AU  - Kiebles JL
FAU - Martinovich, Zoran
AU  - Martinovich Z
FAU - Cohen, Elyse
AU  - Cohen E
FAU - Van Denburg, Alyssa
AU  - Van Denburg A
FAU - Barrett, Terrence A
AU  - Barrett TA
LA  - eng
GR  - R21 AT003204/AT/NCCIH NIH HHS/United States
GR  - R21 AT003204-03/AT/NCCIH NIH HHS/United States
GR  - R21AT003204/AT/NCCIH NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20101230
PL  - England
TA  - Behav Res Ther
JT  - Behaviour research and therapy
JID - 0372477
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Cognitive Behavioral Therapy
MH  - Cross-Over Studies
MH  - Female
MH  - Humans
MH  - *Hypnosis
MH  - Inflammatory Bowel Diseases/*therapy
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Secondary Prevention
MH  - Self Care
MH  - Severity of Illness Index
MH  - Treatment Outcome
PMC - PMC3042537
MID - NIHMS268432
EDAT- 2011/01/25 06:00
MHDA- 2011/07/06 06:00
PMCR- 2012/03/01
CRDT- 2011/01/25 06:00
PHST- 2010/08/30 00:00 [received]
PHST- 2010/10/11 00:00 [revised]
PHST- 2010/12/16 00:00 [accepted]
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/07/06 06:00 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - S0005-7967(10)00254-8 [pii]
AID - 10.1016/j.brat.2010.12.005 [doi]
PST - ppublish
SO  - Behav Res Ther. 2011 Mar;49(3):145-50. doi: 10.1016/j.brat.2010.12.005. Epub 2010 
      Dec 30.