PMID- 21256910
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20231213
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 4
DP  - 2011 Apr
TI  - Human leukocyte antigen (HLA)-E and HLA-G polymorphisms in human papillomavirus 
      infection susceptibility and persistence.
PG  - 337-41
LID - 10.1016/j.humimm.2011.01.010 [doi]
AB  - Human leukocyte antigen (HLA)-E and HLA-G molecules act as powerful modulators of 
      innate and adaptive immune responses. The study examined whether HLA-E and/or 
      HLA-G polymorphisms are associated with human papillomavirus (HPV) infection 
      susceptibility and persistence in 636 female university students in Montreal. 
      HLA-G*01:01:02 and HLA-G*01:01:08 alleles were associated with increased risk of 
      HPV-16 (odds ratio (OR) = 2.10, 95% confidence interval (CI), 1.11-3.96) and any 
      infections with HPV types from alpha species 1, 8, 10, and 13 (OR = 2.72, 95% CI, 
      1.11-6.68). HLA-G*01:01:02 and HLA-G*01:03 alleles were associated with 
      persistent HPV-16 (OR = 2.07, 95% CI, 1.16-3.68) and persistent infections with 
      HPV types from alpha species 2, 3, 4, and 15 (OR = 2.99, 95% CI, 1.12-8.00). HLA-E 
      polymorphism was not associated with risk of acquisition or persistence of HPV 
      infection. These results suggest that HLA-G molecules may play a role in 
      mediating HPV infection risk.
CI  - Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Ferguson, Rhea
AU  - Ferguson R
AD  - Department of Epidemiology, Biostatistics, and Occupational Health, McGill 
      University, Montreal, Canada. michel.roger@ssss.gouv.qc.ca
FAU - Ramanakumar, Agnihotram V
AU  - Ramanakumar AV
FAU - Richardson, Harriet
AU  - Richardson H
FAU - Tellier, Pierre-Paul
AU  - Tellier PP
FAU - Coutlee, Francois
AU  - Coutlee F
FAU - Franco, Eduardo L
AU  - Franco EL
FAU - Roger, Michel
AU  - Roger M
LA  - eng
GR  - MOP-5311/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110120
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cohort Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Papillomaviridae/immunology
MH  - Papillomavirus Infections/*genetics/*immunology
MH  - Polymorphism, Genetic/*genetics
MH  - Young Adult
MH  - HLA-E Antigens
EDAT- 2011/01/25 06:00
MHDA- 2011/07/02 06:00
CRDT- 2011/01/25 06:00
PHST- 2010/10/27 00:00 [received]
PHST- 2010/12/22 00:00 [revised]
PHST- 2011/01/13 00:00 [accepted]
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
AID - S0198-8859(11)00018-8 [pii]
AID - 10.1016/j.humimm.2011.01.010 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Apr;72(4):337-41. doi: 10.1016/j.humimm.2011.01.010. Epub 2011 
      Jan 20.