PMID- 21257150
OWN - NLM
STAT- MEDLINE
DCOM- 20110506
LR  - 20220311
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 151
IP  - 4
DP  - 2011 Apr
TI  - Optical coherence tomography enhanced depth imaging of choroidal tumors.
PG  - 586-593.e2
LID - 10.1016/j.ajo.2010.09.028 [doi]
AB  - PURPOSE: To describe the spectral-domain optical coherence tomography (SD-OCT) 
      features of choroidal tumors imaged using enhanced depth imaging (EDI) technique. 
      DESIGN: Prospective observational case series. METHODS: One tumor each from 23 
      eyes of 23 patients was included. All the patients underwent clinical fundus 
      photography, ultrasonography, and EDI SD-OCT. Qualitative characteristics (tumor 
      outline, reflectivity and/or shadowing of choroidal layers, and detection of 
      inner sclera) and quantitative characteristics (measurement of maximum tumor 
      thickness and the largest tumor diameter) were assessed. RESULTS: Patients 
      (male=12) were categorized as: amelanotic choroidal nevus (4), melanotic 
      choroidal nevus (9), choroidal melanoma (3), circumscribed choroidal hemangioma 
      (3), and choroidal metastasis (4). In all cases, EDI SD-OCT was able to identify 
      the tumor distinctly from the surrounding normal choroid. Qualitative analysis 
      revealed: amelanotic nevi, homogenous and medium reflective band with visible 
      choroidal vessels; melanotic nevi and choroidal melanomas, high reflective band 
      in the anterior choroid with shadowing, and nonvisualization of choroidal vessels 
      and inner sclera; choroidal hemangiomas, medium/low reflective band without 
      shadowing; and choroidal metastasis, low reflective band in the deep choroid with 
      enlargement of the suprachoroidal space. Maximum tumor diameter and thickness was 
      measurable by EDI SD-OCT only in 10 cases that were <9.0 mm in diameter and <1.0 
      mm in thickness (undetectable by ultrasonography). CONCLUSIONS: It is possible to 
      obtain cross-sectional views of a variety of choroidal tumors using EDI SD-OCT. 
      Small choroidal tumors nondetectable by ultrasonography can be objectively 
      measured by this technique.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Torres, Virginia L L
AU  - Torres VL
AD  - Federal University of Sao Paulo, Sao Paulo, Brazil.
FAU - Brugnoni, Nicole
AU  - Brugnoni N
FAU - Kaiser, Peter K
AU  - Kaiser PK
FAU - Singh, Arun D
AU  - Singh AD
LA  - eng
PT  - Journal Article
DEP - 20110122
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Choroid Neoplasms/*diagnosis/pathology
MH  - Female
MH  - Hemangioma/*diagnosis/pathology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Male
MH  - Melanoma/*diagnosis/pathology
MH  - Melanoma, Amelanotic/*diagnosis/pathology
MH  - Nevus/*diagnosis/pathology
MH  - Nevus, Pigmented/*diagnosis/pathology
MH  - Photography
MH  - Prospective Studies
MH  - *Tomography, Optical Coherence
MH  - Ultrasonography
EDAT- 2011/01/25 06:00
MHDA- 2011/05/07 06:00
CRDT- 2011/01/25 06:00
PHST- 2010/03/05 00:00 [received]
PHST- 2010/09/28 00:00 [revised]
PHST- 2010/09/30 00:00 [accepted]
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/05/07 06:00 [medline]
AID - S0002-9394(10)00775-0 [pii]
AID - 10.1016/j.ajo.2010.09.028 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2011 Apr;151(4):586-593.e2. doi: 10.1016/j.ajo.2010.09.028. Epub 
      2011 Jan 22.