PMID- 21258970
OWN - NLM
STAT- MEDLINE
DCOM- 20120316
LR  - 20131121
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 143
IP  - 3
DP  - 2011 Dec
TI  - Zinc and copper levels in severe heart failure and the effects of atrial 
      fibrillation on the zinc and copper status.
PG  - 1239-46
LID - 10.1007/s12011-011-8956-6 [doi]
AB  - Oxidative stress is involved in the pathogenesis of congestive heart failure 
      (CHF). Some trace elements serve as antioxidant defenses. The purpose of this 
      study was to analyze the effect of atrial fibrillation (AF) on zinc (Zn) and 
      copper (Cu) levels in patients with advanced CHF. In this prospective study, 
      serum Zn and Cu levels in 78 patients with clinically advanced CHF, i.e., New 
      York Heart Association (NYHA) functional class III or IV (40 patients with AF and 
      38 in sinus rhythm) were measured using atomic absorption spectrophotometry. All 
      patients also had a left ventricular ejection fraction (EF) of <35%. We recruited 
      40 volunteers with nearly the same age and weight as control. They had normal EF. 
      There was no significant difference between patients with AF and those with sinus 
      rhythm regarding serum Zn and Cu levels. However, both groups showed significant 
      hypozincemia (p < 0.000) and a decreased Zn/Cu ratio (p < 0.03) compared with 
      control group. Serum Cu levels were similar in the two groups and did not differ 
      significantly from the control group. In patients with advanced CHF, irrespective 
      of the rhythm, profound hypozincemia, and a decreased Zn/Cu ratio were present, 
      which could be secondary to the activation of the renin-angiotensin-aldosterone 
      system and CHF medications. The results suggest the need for more studies 
      focusing on possible benefits with Zn nutriceutical replacement in patients with 
      advanced CHF.
FAU - Ghaemian, Ali
AU  - Ghaemian A
AD  - Cardiovascular Department, Mazandaran Heart Center, Mazandaran University of 
      Medical Sciences, Artesh BLVD, Sari, Mazandaran, Iran.
FAU - Salehifar, Ebrahim
AU  - Salehifar E
FAU - Jalalian, Rozita
AU  - Jalalian R
FAU - Ghasemi, Farzad
AU  - Ghasemi F
FAU - Azizi, Soheil
AU  - Azizi S
FAU - Masoumi, Safoora
AU  - Masoumi S
FAU - Shiraj, Hanieh
AU  - Shiraj H
FAU - Mohammadpour, Reza Ali
AU  - Mohammadpour RA
FAU - Bagheri, Gholam Ali
AU  - Bagheri GA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110122
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 789U1901C5 (Copper)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/*blood/physiopathology
MH  - Case-Control Studies
MH  - Copper/*blood
MH  - Female
MH  - Heart Failure/*blood/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Spectrophotometry, Atomic
MH  - Ventricular Function, Left
MH  - Zinc/blood
EDAT- 2011/01/25 06:00
MHDA- 2012/03/17 06:00
CRDT- 2011/01/25 06:00
PHST- 2010/07/31 00:00 [received]
PHST- 2011/01/04 00:00 [accepted]
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2012/03/17 06:00 [medline]
AID - 10.1007/s12011-011-8956-6 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2011 Dec;143(3):1239-46. doi: 10.1007/s12011-011-8956-6. 
      Epub 2011 Jan 22.