PMID- 21259063
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20211020
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 268
IP  - 6
DP  - 2011 Jun
TI  - Expression of matrix metalloproteinases (MMP-2 and MMP-9) in recurrent 
      respiratory papillomas and laryngeal carcinoma: clinical and morphological 
      parallels.
PG  - 871-8
LID - 10.1007/s00405-011-1494-1 [doi]
AB  - The task of the present study was to investigate the expression of MMP-2 and 
      MMP-9 in recurrent respiratory papillomas (RRP) and accomplish a comparative 
      analysis with those in laryngeal squamous cell carcinoma (LSCC). The 
      immunohistochemical expression of MMP-2 and MMP-9 was investigated in specimens 
      taken from RRP (n = 38) and LSCC (n = 39) patient groups, and the normal tissue 
      of vocal fold (n = 12, control group). The expression of MMP-2 and MMP-9, both in 
      epithelium and stroma cells, was graded on a semiquantitative scale, ranging from 
      0 (no expression) to 18 points (high expression). Statistically significant 
      differences in the expression of MMP-2 and MMP-9, both in epithelium and stroma 
      among the RRP, LSCC patients and control group (epithelium) with the LSCC group 
      having the highest MMPs expression scores were revealed. However, no 
      statistically significant correlations among expression of MMPs and clinical 
      and/or morphological features were found in the group of RRP patients. The MMP-2 
      stroma value of 10.4 points was determined as the optimum point (limiting value) 
      for separating RRP and LSCC patient groups. Results of the present study indicate 
      that the expression of both MMP-2 and MMP-9 are up-regulated early in development 
      of laryngeal papillomas, when the benign neoplastic lesion begins and the next 
      determinant step is concerned with the occurrence of malignization. These results 
      seem promising, as they may improve our understanding of the molecular events 
      leading to the papilloma formation and development, however, further research is 
      needed.
FAU - Uloza, Virgilijus
AU  - Uloza V
AD  - Department of Otolaryngology, Kaunas University of Medicine, Eiveniu 2, 50009 
      Kaunas, Lithuania. virgilijus.uloza@kmuk.lt
FAU - Liutkevicius, Vykintas
AU  - Liutkevicius V
FAU - Pangonyte, Dalia
AU  - Pangonyte D
FAU - Saferis, Viktoras
AU  - Saferis V
FAU - Lesauskaite, Vaiva
AU  - Lesauskaite V
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110123
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (Biomarkers, Tumor)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/biosynthesis
MH  - Child
MH  - Child, Preschool
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*enzymology/pathology
MH  - Male
MH  - Matrix Metalloproteinase 2/*biosynthesis
MH  - Matrix Metalloproteinase 9/*biosynthesis
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*enzymology/pathology
MH  - Neoplasm Staging
MH  - Papilloma/*enzymology/pathology
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2011/01/25 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/01/25 06:00
PHST- 2010/07/31 00:00 [received]
PHST- 2011/01/10 00:00 [accepted]
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1007/s00405-011-1494-1 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2011 Jun;268(6):871-8. doi: 10.1007/s00405-011-1494-1. 
      Epub 2011 Jan 23.