PMID- 21259275
OWN - NLM
STAT- MEDLINE
DCOM- 20110509
LR  - 20211020
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Print)
IS  - 0160-9289 (Linking)
VI  - 34
IP  - 1
DP  - 2011 Jan
TI  - Slow cardiac myosin regulatory light chain 2 (MYL2) was down-expressed in chronic 
      heart failure patients.
PG  - 30-4
LID - 10.1002/clc.20832 [doi]
AB  - BACKGROUND: Genetic studies have shown that many slow cardiac myosin regulatory 
      light chain 2 (MYL2) gene mutations can cause hypertrophic cardiomyopathy, which 
      is one of the most common causes of heart failure (HF). But until now there has 
      been no pathological or histological evidence that MYL2 may be associated with HF 
      development. Recent microarray studies indicated that myosin heavy chain 
      expression changed in the pathological process of HF. Because MYL2 is a 
      regulatory component of myosin heavy polypeptide, the role of MYL2 protein in HF 
      needs to be studied. HYPOTHESIS: The level of expression of MYL2 may change in 
      the heart tissue of patients with chronic HF. METHODS: We collected 28 human 
      right auricle samples, 16 from chronic HF patients and 12 from healthy control 
      subjects. Immunohistochemistry was carried out to observe the tissue-expression 
      pattern of the MYL2 protein and Western blot methods were performed to quantify 
      the relative MYL2 expression level. RESULTS: In chronic HF patients, the MYL2 
      protein level decreased significantly compared with normal controls (t test P < 
      0.05). Among the 16 HF patients, MYL2 expression in the severe HF group (New York 
      Heart Association [NYHA] class III or IV) was even lower than that of the 
      moderate HF group (NYHA class II) (t test P < 0.05). CONCLUSIONS: MYL2 was 
      down-expressed in HF tissues, and our findings suggested that MYL2 may play a 
      role in the development and progression of chronic HF.
CI  - Copyright (c) 2010 Wiley Periodicals, Inc.
FAU - Li, Yuanhong
AU  - Li Y
AD  - Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, People's 
      Republic of China.
FAU - Wu, Gang
AU  - Wu G
FAU - Tang, Qizhu
AU  - Tang Q
FAU - Huang, Congxin
AU  - Huang C
FAU - Jiang, Hong
AU  - Jiang H
FAU - Shi, Lisong
AU  - Shi L
FAU - Tu, Xin
AU  - Tu X
FAU - Huang, Jinqi
AU  - Huang J
FAU - Zhu, Xiaoqing
AU  - Zhu X
FAU - Wang, Hongli
AU  - Wang H
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20101210
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (MRLC2 protein, human)
RN  - 0 (Myosin Light Chains)
SB  - IM
CON - Clin Cardiol. 2011 Jan;34(1):10-1. PMID: 21259272
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Blotting, Western
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Down-Regulation
MH  - Female
MH  - Heart Failure/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*chemistry
MH  - Myosin Light Chains/*analysis
MH  - Severity of Illness Index
PMC - PMC6652384
EDAT- 2011/01/25 06:00
MHDA- 2011/05/10 06:00
PMCR- 2010/12/10
CRDT- 2011/01/25 06:00
PHST- 2011/01/25 06:00 [entrez]
PHST- 2011/01/25 06:00 [pubmed]
PHST- 2011/05/10 06:00 [medline]
PHST- 2010/12/10 00:00 [pmc-release]
AID - CLC20832 [pii]
AID - 10.1002/clc.20832 [doi]
PST - ppublish
SO  - Clin Cardiol. 2011 Jan;34(1):30-4. doi: 10.1002/clc.20832. Epub 2010 Dec 10.