PMID- 21262246
OWN - NLM
STAT- MEDLINE
DCOM- 20110715
LR  - 20131121
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 103
IP  - 2
DP  - 2011 May 3
TI  - Regulation by chronic-mild stress of glucocorticoids, monocyte chemoattractant 
      protein-1 and adiposity in rats fed on a high-fat diet.
PG  - 173-80
LID - 10.1016/j.physbeh.2011.01.017 [doi]
AB  - Stress has been reported as a widespread problem and several studies have linked 
      obesity and inflammation-related diseases. Moreover, the combination of suffering 
      from chronic stress and high energy intake might be related to the onset of some 
      metabolic diseases. To study the possible relationships between stress, 
      inflammatory status and obesity, a chronic-mild stress (CMS) paradigm with a 
      high-fat dietary intake model (Cafeteria diet) was implemented on male Wistar 
      rats for 11 weeks. Stress and dietary intake effects on animal adiposity, serum 
      biochemical as well as glucocorticoids and inflammation markers were all 
      analyzed. As expected, consuming a high-fat diet increased body weight, adiposity 
      and insulin resistance in non-stressed animals. A decrease of total white adipose 
      tissue (WAT) and an increase of fecal glucocorticoids, as well as 
      angiotensinogen, and monocyte chemoattractant protein-1 (MCP-1) expression level 
      in retroperitoneal WAT were found only on control-stressed rats. Regarding the 
      serum MCP-1, a decrease was observed on animals under CMS while being fed 
      Cafeteria diet. Furthermore, 11beta-hydroxysteroid dehydrogenase activity, a 
      glucocorticoid and obesity biomarker in the liver, was influenced by high-fat 
      diet intake but not by stress. Finally, statistical analysis showed a strong 
      relation between MCP-1 expression levels in retroperitoneal WAT, fecal 
      corticosterone and total WAT. This trial proved that CMS induced a 
      glucocorticoid-mediated response, which was reduced by the intake of a Cafeteria 
      diet. These findings suggest that a high-fat diet could protect against a stress 
      condition and revealed a different behavior to a stressful environment depending 
      on the nutritional status.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Paternain, L
AU  - Paternain L
AD  - Department of Nutrition and Food Sciences, Physiology and Toxicology, University 
      of Navarra, c/Irunlarrea 1, 31008 Pamplona, Spain.
FAU - Garcia-Diaz, D F
AU  - Garcia-Diaz DF
FAU - Milagro, F I
AU  - Milagro FI
FAU - Gonzalez-Muniesa, P
AU  - Gonzalez-Muniesa P
FAU - Martinez, J A
AU  - Martinez JA
FAU - Campion, J
AU  - Campion J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110122
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Chemokine CCL2)
RN  - 0 (Dietary Fats)
RN  - 11002-13-4 (Angiotensinogen)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenases)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenases/metabolism
MH  - Adipose Tissue, White/drug effects/metabolism
MH  - Adiposity/drug effects/*physiology
MH  - Angiotensinogen/metabolism
MH  - Animals
MH  - Chemokine CCL2/blood/*metabolism
MH  - Corticosterone/*analysis
MH  - Dietary Fats/*pharmacology
MH  - Feces/chemistry
MH  - Insulin Resistance/physiology
MH  - Liver/drug effects/metabolism
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Psychological/*metabolism
EDAT- 2011/01/26 06:00
MHDA- 2011/07/16 06:00
CRDT- 2011/01/26 06:00
PHST- 2010/08/13 00:00 [received]
PHST- 2011/01/11 00:00 [revised]
PHST- 2011/01/16 00:00 [accepted]
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/07/16 06:00 [medline]
AID - S0031-9384(11)00032-1 [pii]
AID - 10.1016/j.physbeh.2011.01.017 [doi]
PST - ppublish
SO  - Physiol Behav. 2011 May 3;103(2):173-80. doi: 10.1016/j.physbeh.2011.01.017. Epub 
      2011 Jan 22.