PMID- 21262311
OWN - NLM
STAT- MEDLINE
DCOM- 20110701
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 4
DP  - 2011 Apr
TI  - The influence of human leukocyte antigen class I alleles and their population 
      frequencies on human immunodeficiency virus type 1 control among African 
      Americans.
PG  - 312-8
LID - 10.1016/j.humimm.2011.01.003 [doi]
AB  - Populations of African ancestry continue to account for a disproportionate burden 
      of the human immunodeficiency virus type 1 (HIV-1) epidemic in the United States. 
      We investigated the effects of human leukocyte antigen (HLA) class I markers in 
      association with virologic and immunologic control of HIV-1 infection among 338 
      HIV-1 subtype B-infected African Americans in 2 cohorts: Reaching for Excellence 
      in Adolescent Care and Health (REACH) and HIV Epidemiology Research Study (HERS). 
      One-year treatment-free interval measurements of HIV-1 RNA viral loads and CD4(+) 
      T cells were examined both separately and combined to represent 3 categories of 
      HIV-1 disease control (76 controllers, 169 intermediates, and 93 noncontrollers). 
      Certain previously or newly implicated HLA class I alleles (A*32, A*36, A*74, 
      B*14, B*1510, B*3501, B*45, B*53, B*57, Cw*04, Cw*08, Cw*12, and Cw*18) were 
      associated with 1 or more of the endpoints in univariate analyses. After 
      multivariable adjustments for other genetic and nongenetic risk factors of HIV-1 
      progression, the subset of alleles more strongly or consistently associated with 
      HIV-1 disease control included A*32, A*74, B*14, B*45, B*53, B*57, and Cw*08. 
      Carriage of infrequent HLA-B but not HLA-A alleles was associated with more 
      favorable disease outcomes. Certain HLA class I associations with control of 
      HIV-1 infection cross the boundaries of race and viral subtype, whereas others 
      appear confined within one or the other of those boundaries.
CI  - Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. All 
      rights reserved.
FAU - Lazaryan, Aleksandr
AU  - Lazaryan A
AD  - University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA.
FAU - Song, Wei
AU  - Song W
FAU - Lobashevsky, Elena
AU  - Lobashevsky E
FAU - Tang, Jianming
AU  - Tang J
FAU - Shrestha, Sadeep
AU  - Shrestha S
FAU - Zhang, Kui
AU  - Zhang K
FAU - McNicholl, Janet M
AU  - McNicholl JM
FAU - Gardner, Lytt I
AU  - Gardner LI
FAU - Wilson, Craig M
AU  - Wilson CM
FAU - Klein, Robert S
AU  - Klein RS
FAU - Rompalo, Anne
AU  - Rompalo A
FAU - Mayer, Kenneth
AU  - Mayer K
FAU - Sobel, Jack
AU  - Sobel J
FAU - Kaslow, Richard A
AU  - Kaslow RA
CN  - HIV Epidemiology Research Study Group
CN  - Reaching for Excellence in Adolescent Care and Health Study Group
LA  - eng
GR  - R01 AI041951/AI/NIAID NIH HHS/United States
GR  - R01 AI071906/AI/NIAID NIH HHS/United States
GR  - U01 HD040533/HD/NICHD NIH HHS/United States
GR  - AI41951/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20110121
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Black or African American/*genetics
MH  - *Alleles
MH  - CD4 Lymphocyte Count
MH  - Female
MH  - Gene Frequency/*genetics
MH  - Genetic Association Studies
MH  - HIV Infections/epidemiology/*genetics
MH  - HIV-1/*immunology
MH  - Histocompatibility Antigens Class I/*genetics/*immunology
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Middle Aged
MH  - Viral Load/genetics
MH  - Young Adult
PMC - PMC3778654
MID - NIHMS506105
FIR - Klein, Robert S
IR  - Klein RS
FIR - Schoenbaum, Ellie
IR  - Schoenbaum E
FIR - Arnsten, Julia
IR  - Arnsten J
FIR - Burk, Robert D
IR  - Burk RD
FIR - Demas, Penelope
IR  - Demas P
FIR - Howard, Andrea
IR  - Howard A
FIR - Schuman, Paula
IR  - Schuman P
FIR - Sobel, Jack
IR  - Sobel J
FIR - Lancaster, Wayne
IR  - Lancaster W
FIR - Rompalo, Anne
IR  - Rompalo A
FIR - Vlahov, David
IR  - Vlahov D
FIR - Celentano, David
IR  - Celentano D
FIR - Carpenter, Charles
IR  - Carpenter C
FIR - Mayer, Kenneth
IR  - Mayer K
FIR - Cu-Uvin, Susan
IR  - Cu-Uvin S
FIR - Flanigan, Timothy
IR  - Flanigan T
FIR - Hogan, Joseph
IR  - Hogan J
FIR - Rich, Josiah
IR  - Rich J
FIR - Gardner, Lytt I
IR  - Gardner LI
FIR - Heilig, Chad
IR  - Heilig C
FIR - Holmberg, Scott D
IR  - Holmberg SD
FIR - Jamieson, Denise J
IR  - Jamieson DJ
FIR - Moore, Janet S
IR  - Moore JS
FIR - Smith, Dawn K
IR  - Smith DK
FIR - Davenny, Katherine
IR  - Davenny K
EDAT- 2011/01/26 06:00
MHDA- 2011/07/02 06:00
PMCR- 2013/09/20
CRDT- 2011/01/26 06:00
PHST- 2010/05/06 00:00 [received]
PHST- 2010/12/09 00:00 [revised]
PHST- 2011/01/13 00:00 [accepted]
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/07/02 06:00 [medline]
PHST- 2013/09/20 00:00 [pmc-release]
AID - S0198-8859(11)00011-5 [pii]
AID - 10.1016/j.humimm.2011.01.003 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Apr;72(4):312-8. doi: 10.1016/j.humimm.2011.01.003. Epub 2011 
      Jan 21.