PMID- 21264102
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 0975-1505 (Electronic)
IS  - 0975-1483 (Print)
IS  - 0975-1483 (Linking)
VI  - 2
IP  - 4
DP  - 2010 Oct
TI  - Anti-tumor Activity of N [(E)-1-(2-hydroxyphenyl) Methylidene], 
      N-[(E)-2-Phenylethylidene], N [(E,2E)-3-Phenyl-2-propenylidene], and N 
      [(E)ethylidene] Isonicotinohydrazide on K562 and Jurkat Cell Lines.
PG  - 399-402
LID - 10.4103/0975-1483.71638 [doi]
AB  - Using the water eliminated mechanism, reactions of 4-pyridinecarboxylic acid 
      hydrazide and salicylaldehyde, benzaldehyde, cinnamaldehyde, and formaldehyde 
      afforded the corresponding N(4)[(E)-1-(2-hydroxyphenyl) methylidene] (NHPM), 
      N(4)-[(E)-2-phenylethylidene] (NPI), N(4)[(E,2E)-3-phenyl-2-propenylidene] 
      (NPPI), and N(4)[(E) ethylidene] (NEI) isonicotinohydrazide, in high yields, 
      after several minutes, as reported. These new compounds have shown antitumor 
      activity against two kinds of cancer cells, which are K562 (human chronic myeloid 
      leukemia) and Jurkat (human T lymphocyte carcinoma).
FAU - Shabani, F
AU  - Shabani F
AD  - Department of Chemistry, Islamic Azad University, Young Researchers Club, 
      Ardabil, Iran.
FAU - Ghammamy, S
AU  - Ghammamy S
FAU - Jahazi, A
AU  - Jahazi A
FAU - Siavoshifar, F
AU  - Siavoshifar F
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Young Pharm
JT  - Journal of young pharmacists : JYP
JID - 101537066
PMC - PMC3019381
OTO - NOTNLM
OT  - 4-pyridinecarboxylic acid hydrazide
OT  - Jurkat
OT  - K562
OT  - isonicotinohydrazide
COIS- Conflict of Interest: None declared.
EDAT- 2011/01/26 06:00
MHDA- 2011/01/26 06:01
PMCR- 2010/10/01
CRDT- 2011/01/26 06:00
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/01/26 06:01 [medline]
PHST- 2010/10/01 00:00 [pmc-release]
AID - S0975-1483(10)24013-X [pii]
AID - JYPharm-2-399 [pii]
AID - 10.4103/0975-1483.71638 [doi]
PST - ppublish
SO  - J Young Pharm. 2010 Oct;2(4):399-402. doi: 10.4103/0975-1483.71638.