PMID- 21264206
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1744-6651 (Print)
IS  - 1744-6651 (Linking)
VI  - 5
IP  - 5
DP  - 2010 Sep 1
TI  - Anterior pituitary adenomas: inherited syndromes, novel genes and molecular 
      pathways.
PG  - 697-709
AB  - Pituitary adenomas are common tumors. Although rarely malignant, pituitary 
      adenomas cause significant morbidity due to mass effects and/or hormonal hypo- 
      and/or hyper-secretion. Molecular understanding of pituitary adenoma formation is 
      essential for the development of medical therapies and the treatment of 
      post-operative recurrences. In general, mutations in genes involved in genetic 
      syndromes associated with pituitary tumors are not a common finding in sporadic 
      lesions. By contrast, multiple endocrine neoplasia type 1 (MEN-1) and aryl 
      hydrocarbon receptor-interacting protein (AIP) mutations may be more frequent 
      among specific subgroups of patients, such as children and young adults, with 
      growth hormone-producing adenomas. In this article, we present the most recent 
      data on the molecular pathogenesis of pituitary adenomas and discuss some of the 
      most recent findings from our laboratory. Guidelines for genetic screening and 
      clinical counseling of patients with pituitary tumors are provided.
FAU - Xekouki, Paraskevi
AU  - Xekouki P
AD  - SEGEN, PDEGEN & Pediatric Endocrinology Program, NICHD, NIH, Building 10, CRC 
      (East Laboratories), Room 1-3330, 10 Center Drive, MSC1103, Bethesda, MD 20892, 
      USA.
FAU - Azevedo, Monalisa
AU  - Azevedo M
FAU - Stratakis, Constantine A
AU  - Stratakis CA
LA  - eng
GR  - ZIA HD000642-13/Intramural NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Expert Rev Endocrinol Metab
JT  - Expert review of endocrinology & metabolism
JID - 101278293
PMC - PMC3024595
MID - NIHMS263685
EDAT- 2011/01/26 06:00
MHDA- 2011/01/26 06:01
PMCR- 2011/07/01
CRDT- 2011/01/26 06:00
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/01/26 06:01 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - 10.1586/eem.10.47 [doi]
PST - ppublish
SO  - Expert Rev Endocrinol Metab. 2010 Sep 1;5(5):697-709. doi: 10.1586/eem.10.47.