PMID- 21264509
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20111110
LR  - 20211020
IS  - 0920-9069 (Print)
IS  - 1573-0778 (Electronic)
IS  - 0920-9069 (Linking)
VI  - 63
IP  - 2
DP  - 2011 Mar
TI  - Inhibitory effect of hot-water extract of quince (Cydonia oblonga) on 
      immunoglobulin E-dependent late-phase immune reactions of mast cells.
PG  - 143-52
LID - 10.1007/s10616-010-9323-8 [doi]
AB  - We evaluated the effect of a crude hot-water extract (HW) of quince (Cydonia 
      oblonga Miller) fruit on immunoglobulin E (IgE)-dependent late-phase immune 
      reactions of mast cells using in vitro system. Mast cell-like RBL-2H3 cells were 
      treated with quince HW and late-phase reaction was then induced by stimulation 
      with IgE + Antigen. Quince HW reduced the elevation of interleukin-13 and tumor 
      necrosis factor-alpha expression level. Furthermore, quince HW suppressed these 
      cytokine expressions of mouse bone marrow-derived mast cells (BMMCs), a normal 
      mast cell model. Leukotriene C(4) and prostaglandin D(2) production in BMMCs 
      after 1 and 6 h of stimulation, respectively, were also reduced by treating the 
      cells with quince HW. We found that the induction of intracellular cyclooxygenase 
      (COX)-2 expression but not COX-1 expression in BMMCs was reduced by quince HW. 
      These results suggest that quince HW has an inhibitory effect on broad range of 
      the late-phase immune reactions of mast cells.
FAU - Kawahara, Takeshi
AU  - Kawahara T
AD  - Laboratory of Food Bioscience, Faculty of Agriculture, Shinshu University, 8304, 
      Minamiminowa, Kamiina, Nagano, 399-4598, Japan, tkawafb@shinshu-u.ac.jp.
FAU - Iizuka, Tatsuhiro
AU  - Iizuka T
LA  - eng
PT  - Journal Article
DEP - 20110126
PL  - United States
TA  - Cytotechnology
JT  - Cytotechnology
JID - 8807027
EIN - Cytotechnology. 2011 Oct;63(5):541-2. PMID: 21779904
PMC - PMC3080480
EDAT- 2011/01/26 06:00
MHDA- 2011/01/26 06:01
PMCR- 2012/03/01
CRDT- 2011/01/26 06:00
PHST- 2010/11/03 00:00 [received]
PHST- 2010/11/23 00:00 [accepted]
PHST- 2011/01/26 06:00 [entrez]
PHST- 2011/01/26 06:00 [pubmed]
PHST- 2011/01/26 06:01 [medline]
PHST- 2012/03/01 00:00 [pmc-release]
AID - 9323 [pii]
AID - 10.1007/s10616-010-9323-8 [doi]
PST - ppublish
SO  - Cytotechnology. 2011 Mar;63(2):143-52. doi: 10.1007/s10616-010-9323-8. Epub 2011 
      Jan 26.