PMID- 21266114
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110126
IS  - 1009-3419 (Print)
IS  - 1009-3419 (Linking)
VI  - 6
IP  - 3
DP  - 2003 Jun 20
TI  - [Studies on proliferation inhibition and anti-invasion of retinoic acid and 
      18beta-glycyrrhetinic acid in highly metastasized human lung cancer cell line].
PG  - 181-4
LID - 10.3779/j.issn.1009-3419.2003.03.04 [doi]
AB  - BACKGROUND: To study the proliferation inhibition and anti-invasion of retinoic 
      acid (RA) and 18beta-glycyrrhetinic acid (GA) in highly metastasized lung cancer 
      cell line (PGCL3), and to observe the combined effects of RA and GA. METHODS: The 
      proliferation inhibitive rate, the colony-formation rate in semi-solid agar, the 
      invasive ability to reconstituted basement membrane, the chemotatic migration 
      ability, the laminin adhesion ability, and the activity of cathepsin B (CB) were 
      tested. RESULTS: Treated with RA and GA, the proliferation of PGCL3 cells were 
      inhibited obviously, and the inhibition degree was related to the dosage of the 
      drugs. IC(5)(0) of the proliferation inhibition were 12.58 mumol/L and 145.3 mumol/L 
      respectively. Treated with 5.0 mumol/L RA, 25 mumol/L and 50 mumol/L GA, the 
      invasive ability was decreased significantly (P < 0.01 and P < 0.001), and the 
      inhibition was in a dose dependent manner. In combined treatment with 5.0 mumol/L 
      RA and 25 mumol/L GA, the inhibition of invasion was greater than the sum of them 
      used alone. Treated with GA of above concentrations and 10 mumol/L RA, the 
      adhesion and migration ability and the secretion of CB of the PGCL3 cells were 
      decreased significantly (P < 0.001). Treated with GA of above concentation, the 
      colony formation rate in semi-solid agar was decreased significantly (P < 
      0.001).. CONCLUSIONS: RA and GA can inhibit the proliferation and invasion of the 
      PGCL3 human lung cancer cells and have the anti-invasion synergism. The mechanism 
      of anti-invasion of RA and GA is to inhibit many points of invasive process.
FAU - Zhang, Dongfang
AU  - Zhang D
AD  - Cancer Institute, Guangzhou Medical College, Guangzhou, Guangdong 510182, 
      P.R.China.
FAU - Huang, Wei
AU  - Huang W
FAU - Huang, Jiqun
AU  - Huang J
FAU - Liao, Zhaoquan
AU  - Liao Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Fei Ai Za Zhi
JT  - Zhongguo fei ai za zhi = Chinese journal of lung cancer
JID - 101126433
EDAT- 2003/06/20 00:00
MHDA- 2003/06/20 00:01
CRDT- 2011/01/27 06:00
PHST- 2011/01/27 06:00 [entrez]
PHST- 2003/06/20 00:00 [pubmed]
PHST- 2003/06/20 00:01 [medline]
AID - 10.3779/j.issn.1009-3419.2003.03.04 [doi]
PST - ppublish
SO  - Zhongguo Fei Ai Za Zhi. 2003 Jun 20;6(3):181-4. doi: 
      10.3779/j.issn.1009-3419.2003.03.04.