PMID- 21266124
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20110126
IS  - 1009-3419 (Print)
IS  - 1009-3419 (Linking)
VI  - 6
IP  - 3
DP  - 2003 Jun 20
TI  - [Efficacy comparison between hyperfractionated and conventional fractionated 
      radiotherapy for non-small cell lung cancer].
PG  - 211-2
LID - 10.3779/j.issn.1009-3419.2003.03.14 [doi]
AB  - BACKGROUND: To investigate the efficacy of hyperfractionated radiotherapy (HRT) 
      for non small cell lung cancer (NSCLC). METHODS: Fifty patients with stage I-III 
      NSCLC were treated in our department from Oct. 1995 to Jan. 2000. All patients 
      had the pathological diagnosis. The patients were divided into two groups 
      according to their entrance sequence: 25 patients were treated by HRT as the 
      treatment group given the tumor doses (DT) 68.9-74.6 Gy/6-6.5 weeks, mean DT 70.3 
      Gy/6-6.5 weeks; 25 patients were irradiated by conventional fractionation (CF) as 
      the control group given DT 64.2-70.4 Gy/6-7 weeks, mean DT 68.6 Gy/6-7 weeks. No 
      patients received chemotherapy or immunotherapy before this treatment. RESULTS: 
      The effective rate after the radiotherapy was 80% (20/25) in the HRT group and 
      48% (12/25) in the CF group (Chi-square=5.56,P < 0.05 ). The 1-, 2-, 3-year 
      survival rate of the HRT group was 68% (17/25), 60% (15/25) and 36% (9/25) 
      respectively. The 1-, 2-, 3-year survival rate of the CF group was 52% (13/25), 
      32% (8/25) and 20% (5/25) respectively. The 2-year survival rate was 
      significantly different between two groups (Chi-square=3.95,P < 0.05 ). The 1-, 
      2-, 3-year local progression free-rate of the HRT group was 72% (18/25), 60% 
      (15/25) and 44% (11/25) respectively. The 1 , 2 , 3 year local progression free 
      rate of the CF group was 64% (16/25), 48% (12/25) and 32% (8/25) respectively. 
      CONCLUSIONS: According to the direct calculation, the efficacy of HRT for NSCLC 
      is higher than that of CF. It is necessary to follow up the long term survival 
      for the patients treated with HRT.
FAU - He, Shengguang
AU  - He S
AD  - Tumor Department, Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, 
      P.R.China.
FAU - Deng, Chunmei
AU  - Deng C
FAU - Xie, Ke
AU  - Xie K
FAU - Lan, Haitao
AU  - Lan H
FAU - Ye, Naiyao
AU  - Ye N
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Fei Ai Za Zhi
JT  - Zhongguo fei ai za zhi = Chinese journal of lung cancer
JID - 101126433
EDAT- 2003/06/20 00:00
MHDA- 2003/06/20 00:01
CRDT- 2011/01/27 06:00
PHST- 2011/01/27 06:00 [entrez]
PHST- 2003/06/20 00:00 [pubmed]
PHST- 2003/06/20 00:01 [medline]
AID - 10.3779/j.issn.1009-3419.2003.03.14 [doi]
PST - ppublish
SO  - Zhongguo Fei Ai Za Zhi. 2003 Jun 20;6(3):211-2. doi: 
      10.3779/j.issn.1009-3419.2003.03.14.