PMID- 21266178
OWN - NLM
STAT- MEDLINE
DCOM- 20110623
LR  - 20110314
IS  - 1095-6840 (Electronic)
IS  - 0016-6480 (Linking)
VI  - 171
IP  - 2
DP  - 2011 Apr 1
TI  - Central injection of des-acyl chicken ghrelin does not affect food intake in 
      chicks.
PG  - 183-8
LID - 10.1016/j.ygcen.2011.01.008 [doi]
AB  - In rodents and goldfish, ghrelin is well known as an orexigenic peptide, and 
      des-acyl ghrelin, which is a ghrelin gene-derived peptide lacking Ser-3 
      acylation, affects feeding behavior when injected with or without ghrelin. 
      Intracerebroventricular (i.c.v.) injection of ghrelin inhibits food intake in 
      chicks (Gallus gallus), but has the opposite effect in rodents and goldfish. The 
      aim of the present study was to investigate the effect of chicken des-acyl 
      ghrelin on feeding in chicks. I.c.v. injection of des-acyl ghrelin alone at doses 
      from 4 to 1000 pmol did not affect food intake in fed and 12-h fasted chicks. 
      Co-injection of des-acyl ghrelin with ghrelin tended to attenuate ghrelin-induced 
      anorexia. In an in vitro study, only the highest concentration (10(-6) M) of 
      des-acyl ghrelin increased intracellular calcium ion concentration in chicken 
      GHS-R1a-expressing cells. Des-acyl ghrelin (10(-6) M) slightly but significantly 
      decreased intracellular calcium ion influx induced by 1 or 3 nM ghrelin. The 
      present results demonstrate that des-acyl ghrelin is not positively involved in 
      the central regulation of feeding in chicks. The feeding regulatory network 
      between ghrelin and des-acyl ghrelin in chicks would be different from those in 
      rodents and goldfish.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Tachibana, Tetsuya
AU  - Tachibana T
AD  - Department of Agrobiological Science, Faculty of Agriculture, Ehime University, 
      Matsuyama 790-8566, Japan. tetsu@agr.ehime-u.ac.jp
FAU - Tanaka, Minoru
AU  - Tanaka M
FAU - Kaiya, Hiroyuki
AU  - Kaiya H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110123
PL  - United States
TA  - Gen Comp Endocrinol
JT  - General and comparative endocrinology
JID - 0370735
RN  - 0 (Ghrelin)
RN  - 0 (ghrelin, des-n-octanoyl)
SB  - IM
MH  - Animals
MH  - Chickens
MH  - Eating/*drug effects
MH  - Ghrelin/administration & dosage/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
EDAT- 2011/01/27 06:00
MHDA- 2011/06/24 06:00
CRDT- 2011/01/27 06:00
PHST- 2010/09/10 00:00 [received]
PHST- 2010/12/29 00:00 [revised]
PHST- 2011/01/13 00:00 [accepted]
PHST- 2011/01/27 06:00 [entrez]
PHST- 2011/01/27 06:00 [pubmed]
PHST- 2011/06/24 06:00 [medline]
AID - S0016-6480(11)00024-4 [pii]
AID - 10.1016/j.ygcen.2011.01.008 [doi]
PST - ppublish
SO  - Gen Comp Endocrinol. 2011 Apr 1;171(2):183-8. doi: 10.1016/j.ygcen.2011.01.008. 
      Epub 2011 Jan 23.