PMID- 21268676
OWN - NLM
STAT- MEDLINE
DCOM- 20110729
LR  - 20211020
IS  - 1744-5094 (Electronic)
IS  - 1381-6810 (Print)
IS  - 1381-6810 (Linking)
VI  - 32
IP  - 2
DP  - 2011 Jun
TI  - Retinal nerve fiber thickness measurements in choroideremia patients with 
      spectral-domain optical coherence tomography.
PG  - 101-6
LID - 10.3109/13816810.2010.544364 [doi]
AB  - PURPOSE: To evaluate the presence of peripapillary retinal nerve fiber layer 
      (RNFL) defects in patients with choroideremia by using spectral-domain optical 
      coherence tomography (SD-OCT). METHODS: Twenty-nine eyes of 16 patients with 
      choroideremia underwent peripapillary RNFL thickness measurements by using 
      SD-OCT. RESULTS: The mean (+/-SD) age of the study population was 44.0 +/- 16.0 years 
      (range, 13-63 years). Thirteen eyes (45%) showed a thinning of the peripapillary 
      RNFL in at least 1 quadrant in either 1 or both eyes. Thinning was most commonly 
      found in the superior (13 eyes) and inferior (10 eyes) quadrants. Twenty-one eyes 
      (72%) showed a thickening of the peripapillary RNFL in at least 1 quadrant in 
      either 1 or both eyes. Of these 21 eyes, all had thickening in the temporal 
      quadrant. Additionally, 2 eyes in each of the other 3 quadrants were found to be 
      abnormally thick. CONCLUSION: Our study demonstrated the presence of defects in 
      the peripapillary RNFL thickness in patients with choroideremia by using SD-OCT. 
      It would be clinically prudent that choroideremia patients considered for various 
      treatment options be considered for RNFL thickness measurements.
FAU - Genead, Mohamed A
AU  - Genead MA
AD  - Department of Ophthalmology and Visual Sciences, University of Illinois at 
      Chicago, Chicago, Illinois, USA.
FAU - McAnany, J Jason
AU  - McAnany JJ
FAU - Fishman, Gerald A
AU  - Fishman GA
LA  - eng
GR  - EY01792/EY/NEI NIH HHS/United States
GR  - P30 EY001792/EY/NEI NIH HHS/United States
GR  - R00 EY019510/EY/NEI NIH HHS/United States
GR  - EY019510/EY/NEI NIH HHS/United States
GR  - K99 EY019510/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110126
PL  - England
TA  - Ophthalmic Genet
JT  - Ophthalmic genetics
JID - 9436057
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Choroideremia/*diagnosis/genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mutation, Missense
MH  - Nerve Fibers/*pathology
MH  - Optic Nerve/*pathology
MH  - Optic Nerve Diseases/*diagnosis
MH  - Prospective Studies
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
PMC - PMC3358001
MID - NIHMS377526
COIS- Declaration of interest: The authors report no conflicts of interest. The authors 
      alone are responsible for the content and writing of the paper
EDAT- 2011/01/28 06:00
MHDA- 2011/07/30 06:00
PMCR- 2012/05/22
CRDT- 2011/01/28 06:00
PHST- 2011/01/28 06:00 [entrez]
PHST- 2011/01/28 06:00 [pubmed]
PHST- 2011/07/30 06:00 [medline]
PHST- 2012/05/22 00:00 [pmc-release]
AID - 10.3109/13816810.2010.544364 [doi]
PST - ppublish
SO  - Ophthalmic Genet. 2011 Jun;32(2):101-6. doi: 10.3109/13816810.2010.544364. Epub 
      2011 Jan 26.