PMID- 21270467
OWN - NLM
STAT- MEDLINE
DCOM- 20110810
LR  - 20191210
IS  - 1708-8283 (Electronic)
IS  - 0883-0738 (Linking)
VI  - 26
IP  - 4
DP  - 2011 Apr
TI  - Idiopathic hypersomnia: a report of three adolescent-onset cases in a 
      two-generation family.
PG  - 522-5
LID - 10.1177/0883073810384865 [doi]
AB  - Idiopathic hypersomnia is an uncommon sleep disorder characterized by prolonged 
      sleep time and excessive daytime sleepiness without cataplexy. This study 
      concerned a case of familial occurrence. The proband expressed an idiopathic 
      hypersomnia with long sleep time at the age of 12 years. Clinical interview and 
      ad libitum polysomnographic study did not reveal any symptoms of narcolepsy or 
      other sleep disorders. Family history revealed that a 20-year-old sister had 
      experienced symptoms of hypersomnia from the age of 16 and their mother had been 
      diagnosed with idiopathic hypersomnia previously. The diagnosis of idiopathic 
      hypersomnia with long sleep time was confirmed in the sister by clinical 
      interview and ad libitum polysomnography. Human leukocyte antigen (HLA) did not 
      reveal the DQB1-0602 phenotype in the proband and relatives. This report confirms 
      the hypothesis of a genetic predisposition in idiopathic hypersomnia.
FAU - Janackova, Sona
AU  - Janackova S
AD  - Neuropediatric Unit, University Hospital of Reims, France. sona.janackova@post.cz
FAU - Motte, Jacques
AU  - Motte J
FAU - Bakchine, Serge
AU  - Bakchine S
FAU - Sforza, Emilia
AU  - Sforza E
LA  - eng
PT  - Journal Article
DEP - 20110126
PL  - United States
TA  - J Child Neurol
JT  - Journal of child neurology
JID - 8606714
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Child
MH  - *Family Health
MH  - Female
MH  - Humans
MH  - Idiopathic Hypersomnia/*genetics/immunology/*physiopathology
MH  - Polysomnography
MH  - Young Adult
EDAT- 2011/01/29 06:00
MHDA- 2011/08/11 06:00
CRDT- 2011/01/29 06:00
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/08/11 06:00 [medline]
AID - 0883073810384865 [pii]
AID - 10.1177/0883073810384865 [doi]
PST - ppublish
SO  - J Child Neurol. 2011 Apr;26(4):522-5. doi: 10.1177/0883073810384865. Epub 2011 
      Jan 26.