PMID- 2127087
OWN - NLM
STAT- MEDLINE
DCOM- 19910401
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 117
IP  - 1-2
DP  - 1990 Sep 4
TI  - Effect of chronic cocaine on dopamine synthesis in the nucleus accumbens as 
      determined by microdialysis perfusion with NSD-1015.
PG  - 234-9
AB  - Reduced steady state formation of dihydroxyphenylalanine (DOPA) (47%) was found 
      in the nucleus accumbens (N. ACC) of rats treated with ten days of repeated 
      cocaine (10 mg/kg, i.p.) as compared to saline controls after NSD 1015 perfusion 
      (10(-4) M) by microdialysis. In addition, prior to NSD 1015 perfusion, basal 
      extracellular levels of the dopamine metabolite, dihydroxyphenylacetic acid 
      (DOPAC) in the N. ACC were 33% lower in the chronic cocaine-treated animals. The 
      results indicate the rate of dopamine synthesis in the N. ACC is significantly 
      reduced by repeated cocaine administration.
FAU - Brock, J W
AU  - Brock JW
AD  - Department of Chemistry, Emory University, Atlanta, GA 30322.
FAU - Ng, J P
AU  - Ng JP
FAU - Justice, J B Jr
AU  - Justice JB Jr
LA  - eng
GR  - DA-05827/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Hydrazines)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 63-84-3 (Dihydroxyphenylalanine)
RN  - A27K5Q85R2 (3-hydroxybenzylhydrazine)
RN  - I5Y540LHVR (Cocaine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Animals
MH  - Cocaine/*pharmacology
MH  - Dialysis/methods
MH  - Dihydroxyphenylalanine/metabolism
MH  - Dopamine/*metabolism
MH  - Hydrazines/*pharmacology
MH  - Kinetics
MH  - Male
MH  - Nucleus Accumbens/drug effects/*metabolism
MH  - Perfusion
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
EDAT- 1990/09/04 00:00
MHDA- 2001/03/28 10:01
CRDT- 1990/09/04 00:00
PHST- 1990/09/04 00:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1990/09/04 00:00 [entrez]
AID - 0304-3940(90)90150-8 [pii]
AID - 10.1016/0304-3940(90)90150-8 [doi]
PST - ppublish
SO  - Neurosci Lett. 1990 Sep 4;117(1-2):234-9. doi: 10.1016/0304-3940(90)90150-8.