PMID- 21270969
OWN - NLM
STAT- MEDLINE
DCOM- 20110526
LR  - 20211020
IS  - 1090-0535 (Electronic)
IS  - 1090-0535 (Linking)
VI  - 17
DP  - 2011 Jan 21
TI  - Clinical and cytogenetic characteristics of choroidal melanoma in Vietnamese 
      Asians.
PG  - 231-6
AB  - PURPOSE: To report the clinical and cytogenetic characteristics of choroidal 
      melanoma in Vietnamese Asians. METHODS: In three Vietnamese Asians with choroidal 
      melanoma, transscleral fine needle aspiration biopsy (FNAB) was performed 
      immediately before iodine-125 brachytherapy. Biopsy was examined for 
      cytopathology, fluorescence in situ hybridization (FISH) for the centromere of 
      chromosome 3, and analyzed by 250K whole genome Mapping Array and U133 plus 2.0 
      Expression Array. RESULTS: Three Vietnamese Asian men (50, 59, and 30 years of 
      age) with clinical diagnosis of choroidal melanoma and no evidence of metastasis 
      had FNAB immediately before Iodine-125 brachytherapy. Cytopathology showed 
      heavily pigmented cells suggestive of or consistent with melanoma. Mapping Array 
      and Expression Array revealed cytogenetic aberrations and gene expression 
      profiles characteristic of choroidal melanoma. One patient (Case 2) with 
      chromosome 3 loss and chromosome 8q gain developed biopsy-proven liver metastasis 
      three years after brachytherapy. One patient (Case 1) with chromosome 6p, 9q and 
      17q gain and a second patient (Case 3) with 6p, 8q and 9q gains and losses in 6q 
      and 8p have had no evidence of metastasis three years after brachytherapy. 
      CONCLUSIONS: In this series of Vietnamese Asians with heavily pigmented choroidal 
      melanoma, the clinical characteristics, cytogenetic aberrations and gene 
      expression profiles were similar to characteristics in other ethnic/racial groups 
      and the cytogenetic aberration of chromosome 3 loss was associated with the 
      development of liver metastasis.
FAU - McCannel, Tara A
AU  - McCannel TA
AD  - Department of Ophthalmology and Jules Stein Eye Institute, University of 
      California, Los Angeles, Los Angeles, CA 90095, USA. TMcCannel@jsei.ucla.edu
FAU - Wu, Melinda Y
AU  - Wu MY
FAU - Burgess, Barry L
AU  - Burgess BL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110121
PL  - United States
TA  - Mol Vis
JT  - Molecular vision
JID - 9605351
RN  - Uveal melanoma
SB  - IM
MH  - Adult
MH  - Biopsy, Fine-Needle
MH  - Choroid Neoplasms/*diagnosis/ethnology/*genetics
MH  - Chromosome Aberrations
MH  - Cytogenetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Liver Neoplasms/secondary
MH  - Melanoma/diagnosis/ethnology/genetics
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Oligonucleotide Array Sequence Analysis
MH  - Prognosis
MH  - Uveal Neoplasms/diagnosis/ethnology/genetics
MH  - Vietnam
PMC - PMC3025820
EDAT- 2011/01/29 06:00
MHDA- 2011/05/27 06:00
PMCR- 2011/01/01
CRDT- 2011/01/29 06:00
PHST- 2010/11/15 00:00 [received]
PHST- 2011/01/17 00:00 [accepted]
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/05/27 06:00 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - 28 [pii]
AID - 2010MOLVIS0497 [pii]
PST - epublish
SO  - Mol Vis. 2011 Jan 21;17:231-6.