PMID- 21272614
OWN - NLM
STAT- MEDLINE
DCOM- 20110718
LR  - 20131121
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 84
IP  - 6
DP  - 2011 Apr 5
TI  - Orphenadrine induces secondarily generalized convulsive status epilepticus in 
      rats.
PG  - 389-93
LID - 10.1016/j.brainresbull.2011.01.014 [doi]
AB  - The current study was aimed to assess the convulsant potency of orphenadrine 
      (ORPH) in rats together with a screen of different conventional antiepileptic 
      drugs (AEDs) on their efficacy to suppress it. ORPH was administered 
      intraperitoneally (i.p.) in doses of 50-80 mg/kg in male Wistar rats. The latency 
      to first seizure, the number of seizure episodes and the duration of overt status 
      epilepticus (SE) as well as the incidence of deaths was scored with simultaneous 
      electroencephalographic (EEG) recordings. Subsequently, the effects of 
      conventional AEDs on ORPH-evoked (80 mg/kg) seizure incidence were studied. ORPH 
      dose-dependently induced seizures in increasing number of animals, reaching 100% 
      at a dose of 80 mg/kg, associated with low mortality and no drug-related 
      neurotoxicity. Epileptic attacks started as complex partial fits consisting of 
      stereotyped behavior, limb movements, head shaking and myoclonic twitches of the 
      body. Subsequently, an overt generalized convulsive SE appeared, lasting for 
      approximately 2h. Among conventional AEDs: carbamazepine, ethosuximide and 
      phenytoin had no effect while valproate (p<0.001), diazepam (p<0.01), and 
      phenobarbital (p<0.001) dose-dependently suppressed seizure activity. All the 
      above characteristics make the new model, a useful, easy to perform experimental 
      tool to study the pathophysiology of SE as well as the effects of new AEDs.
CI  - Copyright (c) 2011 Elsevier Inc. All rights reserved.
FAU - Rejdak, Konrad
AU  - Rejdak K
AD  - Department of Neurology, Medical University of Lublin, 8 Jaczewskiego Str., 
      Lublin, Poland. krejdak@europe.com
FAU - Nieoczym, Dorota
AU  - Nieoczym D
FAU - Czuczwar, Miroslaw
AU  - Czuczwar M
FAU - Kis, Jacek
AU  - Kis J
FAU - Wlaz, Piotr
AU  - Wlaz P
FAU - Turski, Waldemar A
AU  - Turski WA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110125
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Anticonvulsants)
RN  - 0 (Antiparkinson Agents)
RN  - AL805O9OG9 (Orphenadrine)
SB  - IM
MH  - Animals
MH  - Anticonvulsants/therapeutic use
MH  - Antiparkinson Agents/adverse effects
MH  - Dose-Response Relationship, Drug
MH  - Electroencephalography
MH  - Humans
MH  - Male
MH  - Orphenadrine/*adverse effects
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Status Epilepticus/*chemically induced/drug therapy
EDAT- 2011/01/29 06:00
MHDA- 2011/07/19 06:00
CRDT- 2011/01/29 06:00
PHST- 2011/01/03 00:00 [received]
PHST- 2011/01/17 00:00 [accepted]
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/07/19 06:00 [medline]
AID - S0361-9230(11)00017-7 [pii]
AID - 10.1016/j.brainresbull.2011.01.014 [doi]
PST - ppublish
SO  - Brain Res Bull. 2011 Apr 5;84(6):389-93. doi: 10.1016/j.brainresbull.2011.01.014. 
      Epub 2011 Jan 25.