PMID- 21272944
OWN - NLM
STAT- MEDLINE
DCOM- 20110708
LR  - 20110307
IS  - 1873-2534 (Electronic)
IS  - 0165-2427 (Linking)
VI  - 140
IP  - 3-4
DP  - 2011 Apr 15
TI  - A modified live PRRSV vaccine and the pathogenic parent strain induce regulatory 
      T cells in pigs naturally infected with Mycoplasma hyopneumoniae.
PG  - 312-6
LID - 10.1016/j.vetimm.2010.12.011 [doi]
AB  - The lack of heterologous protection by porcine reproductive and respiratory 
      syndrome virus (PRRSV) vaccines is currently a major problem in the field. 
      Heterologous protection by PRRS vaccines depends on the ability of the vaccine to 
      induce an interferon gamma (IFN-gamma) response. One mechanism by which the virus 
      evades the immune system is by activating regulatory T cells (T(regs)), resulting 
      in induction of interleukin 10 rather than IFN-gamma. Our hypothesis that current 
      PRRS vaccines do not differ from pathogenic strains in the ability to induce 
      T(regs) was tested by inoculating three groups of pigs with two pathogenic 
      viruses and an attenuated vaccine strain and evaluating the number of T(regs) in 
      peripheral blood mononuclear cells. Before inoculation, the pigs, although 
      vaccinated became infected naturally with Mycoplasma hyopneumoniae before 
      shipment to our research facility. Our results show that the PRRSV vaccine strain 
      and parent strain are equally able to induce T(regs) in pigs naturally infected 
      with M. hyopneumoniae. Pigs in the vaccine and PRRSV groups had higher lung 
      lesion scores than pigs in the control groups. The results suggest that the 
      exacerbation M. hyopneumoniae respiratory disease may be due to the ability of 
      PRRSV vaccination and viral infection to induce regulatory T cells.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - LeRoith, T
AU  - LeRoith T
AD  - Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine 
      and Infectious Diseases, Virginia-Maryland Regional College of Veterinary 
      Medicine, Blacksburg, VA 24060, USA. tleroith@vt.edu
FAU - Hammond, S
AU  - Hammond S
FAU - Todd, S M
AU  - Todd SM
FAU - Ni, Y
AU  - Ni Y
FAU - Cecere, T
AU  - Cecere T
FAU - Pelzer, K D
AU  - Pelzer KD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110108
PL  - Netherlands
TA  - Vet Immunol Immunopathol
JT  - Veterinary immunology and immunopathology
JID - 8002006
RN  - 0 (Viral Vaccines)
RN  - 130068-27-8 (Interleukin-10)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-10/biosynthesis
MH  - Pneumonia of Swine, Mycoplasmal/*immunology/pathology
MH  - Porcine Reproductive and Respiratory Syndrome/immunology/prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/*immunology/*pathogenicity
MH  - Sus scrofa
MH  - Swine
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - Viral Vaccines/*pharmacology
EDAT- 2011/01/29 06:00
MHDA- 2011/07/09 06:00
CRDT- 2011/01/29 06:00
PHST- 2010/10/20 00:00 [received]
PHST- 2010/12/10 00:00 [revised]
PHST- 2010/12/29 00:00 [accepted]
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2011/07/09 06:00 [medline]
AID - S0165-2427(11)00008-0 [pii]
AID - 10.1016/j.vetimm.2010.12.011 [doi]
PST - ppublish
SO  - Vet Immunol Immunopathol. 2011 Apr 15;140(3-4):312-6. doi: 
      10.1016/j.vetimm.2010.12.011. Epub 2011 Jan 8.