PMID- 21273022
OWN - NLM
STAT- MEDLINE
DCOM- 20120517
LR  - 20120110
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 81
IP  - 2
DP  - 2012 Feb
TI  - Changes in thalamus connectivity in mild cognitive impairment: evidence from 
      resting state fMRI.
PG  - 277-85
LID - 10.1016/j.ejrad.2010.12.044 [doi]
AB  - PURPOSE: The subcortical region such as thalamus was believed to have close 
      relationship with many cerebral cortexes which made it especially interesting in 
      the study of functional connectivity. Here, we used resting state functional MRI 
      (fMRI) to examine changes in thalamus connectivity in mild cognitive impairment 
      (MCI), which presented a neuro-disconnection syndrome. MATERIALS AND METHODS: 
      Data from 14 patients and 14 healthy age-matched controls were analyzed. Thalamus 
      connectivity was investigated by examination of the correlation between low 
      frequency fMRI signal fluctuations in the thalamus and those in all other brain 
      regions. RESULTS: We found that functional connectivity between the left thalamus 
      and a set of regions was decreased in MCI; these regions are: bilateral cuneus, 
      middle occipital gyrus (MOG), superior frontal gyrus (SFG), medial prefrontal 
      cortex (MPFC), precuneus, inferior frontal gyrus (IFG) and precentral gyrus 
      (PreCG). There are also some regions showed reduced connectivity to right 
      thalamus; these regions are bilateral cuneus, MOG, fusiform gyrus (FG), MPFC, 
      paracentral lobe (PCL), precuneus, superior parietal lobe (SPL) and IFG. We also 
      found increased functional connectivity between the left thalamus and the right 
      thalamus in MCI. CONCLUSION: The decreased connectivity between the thalamus and 
      the other brain regions might indicate reduced integrity of thalamus-related 
      cortical networks in MCI. Furthermore, the increased connectivity between the 
      left and right thalamus suggest compensation for the loss of cognitive function. 
      Briefly, impairment and compensation of thalamus connectivity coexist in the MCI 
      patients.
CI  - Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
FAU - Wang, Zhiqun
AU  - Wang Z
AD  - Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing 
      100053, PR China.
FAU - Jia, Xiuqin
AU  - Jia X
FAU - Liang, Peipeng
AU  - Liang P
FAU - Qi, Zhigang
AU  - Qi Z
FAU - Yang, Yanhui
AU  - Yang Y
FAU - Zhou, Weidong
AU  - Zhou W
FAU - Li, Kuncheng
AU  - Li K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110126
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Aged
MH  - Brain Mapping/*methods
MH  - Cognition Disorders/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Nerve Net/*physiopathology
MH  - Rest
MH  - Thalamus/*physiopathology
EDAT- 2011/01/29 06:00
MHDA- 2012/05/18 06:00
CRDT- 2011/01/29 06:00
PHST- 2010/10/12 00:00 [received]
PHST- 2010/12/17 00:00 [accepted]
PHST- 2011/01/29 06:00 [entrez]
PHST- 2011/01/29 06:00 [pubmed]
PHST- 2012/05/18 06:00 [medline]
AID - S0720-048X(10)00669-8 [pii]
AID - 10.1016/j.ejrad.2010.12.044 [doi]
PST - ppublish
SO  - Eur J Radiol. 2012 Feb;81(2):277-85. doi: 10.1016/j.ejrad.2010.12.044. Epub 2011 
      Jan 26.